Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code
Summary: Hippocampal subfield CA3 is thought to stably store memories in assemblies of recurrently connected cells functioning as a collective. However, the collective hippocampal coding properties that are unique to CA3 and how such properties facilitate the stability or precision of the neural cod...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723001304 |
| _version_ | 1797903516644147200 |
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| author | Liron Sheintuch Nitzan Geva Daniel Deitch Alon Rubin Yaniv Ziv |
| author_facet | Liron Sheintuch Nitzan Geva Daniel Deitch Alon Rubin Yaniv Ziv |
| author_sort | Liron Sheintuch |
| collection | DOAJ |
| description | Summary: Hippocampal subfield CA3 is thought to stably store memories in assemblies of recurrently connected cells functioning as a collective. However, the collective hippocampal coding properties that are unique to CA3 and how such properties facilitate the stability or precision of the neural code remain unclear. Here, we performed large-scale Ca2+ imaging in hippocampal CA1 and CA3 of freely behaving mice that repeatedly explored the same, initially novel environments over weeks. CA3 place cells have more precise and more stable tuning and show a higher statistical dependence with their peers compared with CA1 place cells, uncovering a cell assembly organization in CA3. Surprisingly, although tuning precision and long-term stability are correlated, cells with stronger peer dependence exhibit higher stability but not higher precision. Overall, our results expose the three-way relationship between tuning precision, long-term stability, and peer dependence, suggesting that a cell assembly organization underlies long-term storage of information in the hippocampus. |
| first_indexed | 2024-04-10T09:34:15Z |
| format | Article |
| id | doaj.art-6cc339ad0a944c1d8d340c549661e66d |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-10T09:34:15Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-6cc339ad0a944c1d8d340c549661e66d2023-02-18T04:16:47ZengElsevierCell Reports2211-12472023-02-01422112119Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial codeLiron Sheintuch0Nitzan Geva1Daniel Deitch2Alon Rubin3Yaniv Ziv4Department of Brain Sciences, Weizmann Institute of Science, Rehovot, IsraelDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot, IsraelDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot, IsraelDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel; Corresponding authorDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel; Corresponding authorSummary: Hippocampal subfield CA3 is thought to stably store memories in assemblies of recurrently connected cells functioning as a collective. However, the collective hippocampal coding properties that are unique to CA3 and how such properties facilitate the stability or precision of the neural code remain unclear. Here, we performed large-scale Ca2+ imaging in hippocampal CA1 and CA3 of freely behaving mice that repeatedly explored the same, initially novel environments over weeks. CA3 place cells have more precise and more stable tuning and show a higher statistical dependence with their peers compared with CA1 place cells, uncovering a cell assembly organization in CA3. Surprisingly, although tuning precision and long-term stability are correlated, cells with stronger peer dependence exhibit higher stability but not higher precision. Overall, our results expose the three-way relationship between tuning precision, long-term stability, and peer dependence, suggesting that a cell assembly organization underlies long-term storage of information in the hippocampus.http://www.sciencedirect.com/science/article/pii/S2211124723001304CP: Neuroscience |
| spellingShingle | Liron Sheintuch Nitzan Geva Daniel Deitch Alon Rubin Yaniv Ziv Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code Cell Reports CP: Neuroscience |
| title | Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code |
| title_full | Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code |
| title_fullStr | Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code |
| title_full_unstemmed | Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code |
| title_short | Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code |
| title_sort | organization of hippocampal ca3 into correlated cell assemblies supports a stable spatial code |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723001304 |
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