CONTEMPORARY TENDENCIES IN CONSTRUCTING RECOMBINANT VACCINES FOR SPECIFIC PROPHYLAXIS OF PLAGUE
An importance place in the system of prophylaxis measures against plague is allotted to vaccination of population contingents, that belong to risk groups for infection. The whole arsenal of accumulated knowledge on structure, properties, molecular nature, genetic determination, synthesis pathways, r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2015-06-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.crie.ru/jour/article/view/14106 |
| _version_ | 1827903067914240000 |
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| author | N. I Mikshis O. M Kudryavtseva V. V Kutyrev |
| author_facet | N. I Mikshis O. M Kudryavtseva V. V Kutyrev |
| author_sort | N. I Mikshis |
| collection | DOAJ |
| description | An importance place in the system of prophylaxis measures against plague is allotted to vaccination of population contingents, that belong to risk groups for infection. The whole arsenal of accumulated knowledge on structure, properties, molecular nature, genetic determination, synthesis pathways, regulation and mechanisms of interaction with macroorganism of pathogenicity factors and immunogenicity of the infectious disease causative agent is used in the creation of new generation of vaccines. Contemporary technologies - genomics, proteomics, reverse vaccinol-ogy facilitate detection of protective antigens and help determine rational design of the vaccines. Main tendencies in development of recombinant live and chemical vaccines for specific prophylaxis of plague are presented in the review. Constructive approaches, that allow to produce highly effective and safe preparations are isolated. |
| first_indexed | 2024-03-13T00:07:46Z |
| format | Article |
| id | doaj.art-6cc33e80d8fd419ca13d1348887affc7 |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-03-13T00:07:46Z |
| publishDate | 2015-06-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-6cc33e80d8fd419ca13d1348887affc72023-07-12T20:20:08ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132015-06-019231161262531CONTEMPORARY TENDENCIES IN CONSTRUCTING RECOMBINANT VACCINES FOR SPECIFIC PROPHYLAXIS OF PLAGUEN. I Mikshis0O. M Kudryavtseva1V. V Kutyrev2Russian Research Institute of Plague Control «Microb»Russian Research Institute of Plague Control «Microb»Russian Research Institute of Plague Control «Microb»An importance place in the system of prophylaxis measures against plague is allotted to vaccination of population contingents, that belong to risk groups for infection. The whole arsenal of accumulated knowledge on structure, properties, molecular nature, genetic determination, synthesis pathways, regulation and mechanisms of interaction with macroorganism of pathogenicity factors and immunogenicity of the infectious disease causative agent is used in the creation of new generation of vaccines. Contemporary technologies - genomics, proteomics, reverse vaccinol-ogy facilitate detection of protective antigens and help determine rational design of the vaccines. Main tendencies in development of recombinant live and chemical vaccines for specific prophylaxis of plague are presented in the review. Constructive approaches, that allow to produce highly effective and safe preparations are isolated.https://microbiol.crie.ru/jour/article/view/14106yersinia pestisyersinia pestisplaguerecombinant plague vaccines |
| spellingShingle | N. I Mikshis O. M Kudryavtseva V. V Kutyrev CONTEMPORARY TENDENCIES IN CONSTRUCTING RECOMBINANT VACCINES FOR SPECIFIC PROPHYLAXIS OF PLAGUE Журнал микробиологии, эпидемиологии и иммунобиологии yersinia pestis yersinia pestis plague recombinant plague vaccines |
| title | CONTEMPORARY TENDENCIES IN CONSTRUCTING RECOMBINANT VACCINES FOR SPECIFIC PROPHYLAXIS OF PLAGUE |
| title_full | CONTEMPORARY TENDENCIES IN CONSTRUCTING RECOMBINANT VACCINES FOR SPECIFIC PROPHYLAXIS OF PLAGUE |
| title_fullStr | CONTEMPORARY TENDENCIES IN CONSTRUCTING RECOMBINANT VACCINES FOR SPECIFIC PROPHYLAXIS OF PLAGUE |
| title_full_unstemmed | CONTEMPORARY TENDENCIES IN CONSTRUCTING RECOMBINANT VACCINES FOR SPECIFIC PROPHYLAXIS OF PLAGUE |
| title_short | CONTEMPORARY TENDENCIES IN CONSTRUCTING RECOMBINANT VACCINES FOR SPECIFIC PROPHYLAXIS OF PLAGUE |
| title_sort | contemporary tendencies in constructing recombinant vaccines for specific prophylaxis of plague |
| topic | yersinia pestis yersinia pestis plague recombinant plague vaccines |
| url | https://microbiol.crie.ru/jour/article/view/14106 |
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