Biological roles of RNA m7G modification and its implications in cancer
Abstract M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological func...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Biology Direct |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13062-023-00414-5 |
| _version_ | 1797453611867832320 |
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| author | Xin Zhang Wen-Yan Zhu Shu-Yi Shen Jia-Hao Shen Xiao-Dong Chen |
| author_facet | Xin Zhang Wen-Yan Zhu Shu-Yi Shen Jia-Hao Shen Xiao-Dong Chen |
| author_sort | Xin Zhang |
| collection | DOAJ |
| description | Abstract M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. In addition, there is growing evidence that m7G modifications are crucial in the emergence of cancer. Here, we review the most recent findings regarding the detection techniques, distribution, biological functions and Regulators of m7G. We also summarize the connections between m7G modifications and cancer development, drug resistance, and tumor microenvironment as well as we discuss the research’s future directions and trends. |
| first_indexed | 2024-03-09T15:25:20Z |
| format | Article |
| id | doaj.art-6cc36e86a5404b0db611cd2dba7a56e3 |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-03-09T15:25:20Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-6cc36e86a5404b0db611cd2dba7a56e32023-11-26T12:34:28ZengBMCBiology Direct1745-61502023-09-0118111410.1186/s13062-023-00414-5Biological roles of RNA m7G modification and its implications in cancerXin Zhang0Wen-Yan Zhu1Shu-Yi Shen2Jia-Hao Shen3Xiao-Dong Chen4Department of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityDepartment of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityDepartment of Dermatology, the First Affiliated Hospital of Fujian Medical UniversityDepartment of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityDepartment of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityAbstract M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. In addition, there is growing evidence that m7G modifications are crucial in the emergence of cancer. Here, we review the most recent findings regarding the detection techniques, distribution, biological functions and Regulators of m7G. We also summarize the connections between m7G modifications and cancer development, drug resistance, and tumor microenvironment as well as we discuss the research’s future directions and trends.https://doi.org/10.1186/s13062-023-00414-5N7-methylguanosineImmune microenvironmentRNA methylation modificationCarcinoma |
| spellingShingle | Xin Zhang Wen-Yan Zhu Shu-Yi Shen Jia-Hao Shen Xiao-Dong Chen Biological roles of RNA m7G modification and its implications in cancer Biology Direct N7-methylguanosine Immune microenvironment RNA methylation modification Carcinoma |
| title | Biological roles of RNA m7G modification and its implications in cancer |
| title_full | Biological roles of RNA m7G modification and its implications in cancer |
| title_fullStr | Biological roles of RNA m7G modification and its implications in cancer |
| title_full_unstemmed | Biological roles of RNA m7G modification and its implications in cancer |
| title_short | Biological roles of RNA m7G modification and its implications in cancer |
| title_sort | biological roles of rna m7g modification and its implications in cancer |
| topic | N7-methylguanosine Immune microenvironment RNA methylation modification Carcinoma |
| url | https://doi.org/10.1186/s13062-023-00414-5 |
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