Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway

Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway

Abstract Background Sepsis is a life-threatening organ dysfunction syndrome resulted from severe infection with high morbidity and mortality. Cluster of differentiation 38 (CD38) is a multifunctional type II transmembrane glycoprotein widely expressed on the surface of various immunocytes membranes...

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Bibliographic Details
Main Authors: Yujie Guo, Huiqing Zhang, Zhe Lv, Yuna Du, Dan Li, Hui Fang, Jing You, Lijun Yu, Rong Li
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell Communication and Signaling
Subjects:
Daphnetin
Sepsis
Lung injury
CD38
Inflammation
Pyroptosis
Online Access:https://doi.org/10.1186/s12964-023-01041-3

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