Distinct Effects of Interleukin-1β Inhibition upon Cytokine Profile in Patients with Adult-Onset Still’s Disease and Active Articular Manifestation Responding to Canakinumab

Distinct Effects of Interleukin-1β Inhibition upon Cytokine Profile in Patients with Adult-Onset Still’s Disease and Active Articular Manifestation Responding to Canakinumab

Adult-onset Still’s disease (AOSD) is a systemic auto-inflammatory disease characterized by the presence of immunologically mediated inflammation and deficient resolution of inflammation. Canakinumab is an approved IL-1β inhibitor in the treatment of AOSD with a balanced efficacy and safety profile....

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Bibliographic Details
Main Authors: Khetam Ghannam, Jan Zernicke, Claudia Kedor, Joachim Listing, Gerd-R. Burmester, Dirk Foell, Eugen Feist
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Clinical Medicine
Subjects:
adult-onset Still’s disease
canakinumab
cytokines
Online Access:https://www.mdpi.com/2077-0383/10/19/4400

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