School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial [version 2; peer review: 2 approved]
Background Dengue is the most common and widespread mosquito-borne arboviral disease globally estimated to cause >390 million infections and >20,000 deaths annually. There are no effective preventive drugs and the newly introduced vaccines are not yet available. Control of dengue transmission...
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| Format: | Article |
| Language: | English |
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Wellcome
2023-12-01
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| Series: | Wellcome Open Research |
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| Online Access: | https://wellcomeopenresearch.org/articles/7-206/v2 |
| _version_ | 1797330186834804736 |
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| author | Mavuto Mukaka Nay Yi Yi Linn Hans J. Overgaard Leo Braack Aye Mon Mon Kyaw Sheri Bastien Myo Win Tin Pierre Echaubard Fiona Vande Velde Win Zaw Richard Maude |
| author_facet | Mavuto Mukaka Nay Yi Yi Linn Hans J. Overgaard Leo Braack Aye Mon Mon Kyaw Sheri Bastien Myo Win Tin Pierre Echaubard Fiona Vande Velde Win Zaw Richard Maude |
| author_sort | Mavuto Mukaka |
| collection | DOAJ |
| description | Background Dengue is the most common and widespread mosquito-borne arboviral disease globally estimated to cause >390 million infections and >20,000 deaths annually. There are no effective preventive drugs and the newly introduced vaccines are not yet available. Control of dengue transmission still relies primarily on mosquito vector control. Although most vector control methods currently used by national dengue control programs may temporarily reduce mosquito populations, there is little evidence that they affect transmission. There is an urgent need for innovative, participatory, effective, and locally adapted approaches for sustainable vector control and monitoring in which students can be particularly relevant contributors and to demonstrate a clear link between vector reduction and dengue transmission reduction, using tools that are inexpensive and easy to use by local communities in a sustainable manner. Methods Here we describe a cluster randomized controlled trial to be conducted in 46 school catchment areas in two townships in Yangon, Myanmar. The outcome measures are dengue cases confirmed by rapid diagnostic test in the townships, dengue incidence in schools, entomological indices, knowledge, attitudes and practice, behavior, and engagement. Conclusions The trial involves middle school students that positions them to become actors in dengue knowledge transfer to their communities and take a leadership role in the delivery of vector control interventions and monitoring methods. Following this rationale, we believe that students can become change agents of decentralized vector surveillance and sustainable disease control in line with recent new paradigms in integrated and participatory vector surveillance and control. This provides an opportunity to operationalize transdisciplinary research towards sustainable health development. Due to the COVID-19 pandemic and political instability in Myanmar the project has been terminated by the donor, but the protocol will be helpful for potential future implementation of the project in Myanmar and/or elsewhere. Registration: This trial was registered in the ISRCTN Registry on 31 May 2022 (https://doi.org/10.1186/ISRCTN78254298). |
| first_indexed | 2024-03-08T07:16:25Z |
| format | Article |
| id | doaj.art-6cc522ed1f86482eb5adef188c00289a |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-03-08T07:16:25Z |
| publishDate | 2023-12-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-6cc522ed1f86482eb5adef188c00289a2024-02-03T01:00:00ZengWellcomeWellcome Open Research2398-502X2023-12-01722970School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial [version 2; peer review: 2 approved]Mavuto Mukaka0Nay Yi Yi Linn1Hans J. Overgaard2https://orcid.org/0000-0001-7604-3785Leo Braack3Aye Mon Mon Kyaw4Sheri Bastien5https://orcid.org/0000-0002-4351-5704Myo Win Tin6Pierre Echaubard7Fiona Vande Velde8Win Zaw9https://orcid.org/0000-0002-9852-3357Richard Maude10https://orcid.org/0000-0002-5355-0562Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandCentral Vector Borne Disease Control Unit, Ministry of Health and Sports, Nay Pyi Taw, MyanmarFaculty of Science and Technology, Norwegian University of Life Sciences, As, 1432, NorwayMalaria Consortium, Bangkok 10400, ThailandYangon Regional Health Department, Ministry of Health and Sports, Yangon, MyanmarFaculty of Landscape and Society, Norwegian University of Life Sciences, 1432 Ås, NorwayMalaria Consortium, Yangon 11041, MyanmarSchool of Oriental and African Studies (SOAS), University of London, London, WC1H 0XG, UKFaculty of Landscape and Society, Norwegian University of Life Sciences, 1432 Ås, NorwayMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandBackground Dengue is the most common and widespread mosquito-borne arboviral disease globally estimated to cause >390 million infections and >20,000 deaths annually. There are no effective preventive drugs and the newly introduced vaccines are not yet available. Control of dengue transmission still relies primarily on mosquito vector control. Although most vector control methods currently used by national dengue control programs may temporarily reduce mosquito populations, there is little evidence that they affect transmission. There is an urgent need for innovative, participatory, effective, and locally adapted approaches for sustainable vector control and monitoring in which students can be particularly relevant contributors and to demonstrate a clear link between vector reduction and dengue transmission reduction, using tools that are inexpensive and easy to use by local communities in a sustainable manner. Methods Here we describe a cluster randomized controlled trial to be conducted in 46 school catchment areas in two townships in Yangon, Myanmar. The outcome measures are dengue cases confirmed by rapid diagnostic test in the townships, dengue incidence in schools, entomological indices, knowledge, attitudes and practice, behavior, and engagement. Conclusions The trial involves middle school students that positions them to become actors in dengue knowledge transfer to their communities and take a leadership role in the delivery of vector control interventions and monitoring methods. Following this rationale, we believe that students can become change agents of decentralized vector surveillance and sustainable disease control in line with recent new paradigms in integrated and participatory vector surveillance and control. This provides an opportunity to operationalize transdisciplinary research towards sustainable health development. Due to the COVID-19 pandemic and political instability in Myanmar the project has been terminated by the donor, but the protocol will be helpful for potential future implementation of the project in Myanmar and/or elsewhere. Registration: This trial was registered in the ISRCTN Registry on 31 May 2022 (https://doi.org/10.1186/ISRCTN78254298).https://wellcomeopenresearch.org/articles/7-206/v2Dengue incidence school KAP community engagement implementation fidelity Aedes eng |
| spellingShingle | Mavuto Mukaka Nay Yi Yi Linn Hans J. Overgaard Leo Braack Aye Mon Mon Kyaw Sheri Bastien Myo Win Tin Pierre Echaubard Fiona Vande Velde Win Zaw Richard Maude School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial [version 2; peer review: 2 approved] Wellcome Open Research Dengue incidence school KAP community engagement implementation fidelity Aedes eng |
| title | School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial [version 2; peer review: 2 approved] |
| title_full | School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial [version 2; peer review: 2 approved] |
| title_fullStr | School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial [version 2; peer review: 2 approved] |
| title_full_unstemmed | School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial [version 2; peer review: 2 approved] |
| title_short | School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial [version 2; peer review: 2 approved] |
| title_sort | school and community driven dengue vector control and monitoring in myanmar study protocol for a cluster randomized controlled trial version 2 peer review 2 approved |
| topic | Dengue incidence school KAP community engagement implementation fidelity Aedes eng |
| url | https://wellcomeopenresearch.org/articles/7-206/v2 |
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