Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management
Acute kidney injury (AKI) is a common clinical condition, results in patient morbidity and mortality, and incurs considerable health care costs. Sepsis, ischaemia-reperfusion injury (IRI) and drug nephrotoxicity are the leading causes. Mounting evidence suggests that perturbations in circular RNAs (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8509 |
| _version_ | 1797432839725121536 |
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| author | Benjamin Y. F. So Desmond Y. H. Yap Tak Mao Chan |
| author_facet | Benjamin Y. F. So Desmond Y. H. Yap Tak Mao Chan |
| author_sort | Benjamin Y. F. So |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a common clinical condition, results in patient morbidity and mortality, and incurs considerable health care costs. Sepsis, ischaemia-reperfusion injury (IRI) and drug nephrotoxicity are the leading causes. Mounting evidence suggests that perturbations in circular RNAs (circRNAs) are observed in AKI of various aetiologies, and have pathogenic significance. Aberrant circRNA expressions can cause altered intracellular signalling, exaggerated oxidative stress, increased cellular apoptosis, excess inflammation, and tissue injury in AKI due to sepsis or IRI. While circRNAs are dysregulated in drug-induced AKI, their roles in pathogenesis are less well-characterised. CircRNAs also show potential for clinical application in diagnosis, prognostication, monitoring, and treatment. Prospective observational studies are needed to investigate the role of circRNAs in the clinical management of AKI, with special focus on the safety of therapeutic interventions targeting circRNAs and the avoidance of untoward off-target effects. |
| first_indexed | 2024-03-09T10:08:37Z |
| format | Article |
| id | doaj.art-6cc57851a0894582b514f88af2a6bde0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:08:37Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6cc57851a0894582b514f88af2a6bde02023-12-01T22:57:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315850910.3390/ijms23158509Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical ManagementBenjamin Y. F. So0Desmond Y. H. Yap1Tak Mao Chan2Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, ChinaDivision of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, ChinaDivision of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, ChinaAcute kidney injury (AKI) is a common clinical condition, results in patient morbidity and mortality, and incurs considerable health care costs. Sepsis, ischaemia-reperfusion injury (IRI) and drug nephrotoxicity are the leading causes. Mounting evidence suggests that perturbations in circular RNAs (circRNAs) are observed in AKI of various aetiologies, and have pathogenic significance. Aberrant circRNA expressions can cause altered intracellular signalling, exaggerated oxidative stress, increased cellular apoptosis, excess inflammation, and tissue injury in AKI due to sepsis or IRI. While circRNAs are dysregulated in drug-induced AKI, their roles in pathogenesis are less well-characterised. CircRNAs also show potential for clinical application in diagnosis, prognostication, monitoring, and treatment. Prospective observational studies are needed to investigate the role of circRNAs in the clinical management of AKI, with special focus on the safety of therapeutic interventions targeting circRNAs and the avoidance of untoward off-target effects.https://www.mdpi.com/1422-0067/23/15/8509acute kidney injurycircular RNAssepsisischaemia-reperfusion injurydrugs |
| spellingShingle | Benjamin Y. F. So Desmond Y. H. Yap Tak Mao Chan Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management International Journal of Molecular Sciences acute kidney injury circular RNAs sepsis ischaemia-reperfusion injury drugs |
| title | Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management |
| title_full | Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management |
| title_fullStr | Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management |
| title_full_unstemmed | Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management |
| title_short | Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management |
| title_sort | circular rnas in acute kidney injury roles in pathophysiology and implications for clinical management |
| topic | acute kidney injury circular RNAs sepsis ischaemia-reperfusion injury drugs |
| url | https://www.mdpi.com/1422-0067/23/15/8509 |
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