Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women
Aim:To assess the risk factors associated with high rate of insufficient endometrial sampling on endometrial biopsy in postmenopausal women.Methods:Data were retrieved from the records of 522 consecutive patients who underwent endometrial sampling. Logistic regression analyses were performed to dete...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-01-01
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| Series: | Haseki Tıp Bülteni |
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http://www.hasekidergisi.com/archives/archive-detail/article-preview/factors-associated-with-nsufficient-endometrial-sa/35946
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| _version_ | 1797914593753825280 |
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| author | Seda Ateş Ayşe Filiz Gökmen Karasu Halime Çalı Zeynep Soyman Ömer Uysal |
| author_facet | Seda Ateş Ayşe Filiz Gökmen Karasu Halime Çalı Zeynep Soyman Ömer Uysal |
| author_sort | Seda Ateş |
| collection | DOAJ |
| description | Aim:To assess the risk factors associated with high rate of insufficient endometrial sampling on endometrial biopsy in postmenopausal women.Methods:Data were retrieved from the records of 522 consecutive patients who underwent endometrial sampling. Logistic regression analyses were performed to determine various factors associated with scanty endometrial biopsy. The exclusion criteria included patient refusal, uncertain menopausal status, cervical carcinoma detected after sampling and unavailable records.Results:The sample was insufficient for a definitive diagnosis in 143 (25.9%) patients. Out of these, 53 cases were investigated with invasive procedures. Further histopathological examination revealed that five (9.4%) patients had uterine malignancy. Based on the multivariate analysis, time since the onset of menopause [Odds ratio (OR)=1.044, 95% confidence interval (CI)=1.000-1.090, p=0.049] was significantly associated with insufficient endometrial biopsy in cases with a endometrial thickness of >12 mm on ultrasonography (OR=0.624, 95% CI=0.472-0.824, p=0.001). The use of dilation and curettage technique (OR=0.662, 95% CI=0.522-0.841, p=0.001) decreased the risk of insufficient sampling on endometrial biopsy.Conclusion:Time since the onset of menopause and the thickness of endometrium were significant independent factors associated with insufficient sample. Using Karman cannula for endometrial aspiration may not be a reliable method in the evaluation of postmenopausal women. An insufficient endometrial sample does not rule out endometrial carcinoma, therefore, a further histopathological examination is recommended. |
| first_indexed | 2024-04-10T12:29:47Z |
| format | Article |
| id | doaj.art-6cc5b57dec5444e3a9cf17fb1540b828 |
| institution | Directory Open Access Journal |
| issn | 1302-0072 2147-2688 |
| language | English |
| last_indexed | 2024-04-10T12:29:47Z |
| publishDate | 2020-01-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj.art-6cc5b57dec5444e3a9cf17fb1540b8282023-02-15T16:14:59ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882020-01-01581657110.4274/haseki.galenos.2019.558413049054Factors Associated with Insufficient Endometrial Sampling in Postmenopausal WomenSeda Ateş0Ayşe Filiz Gökmen Karasu1Halime Çalı2Zeynep Soyman3Ömer Uysal4 Bezmialem Vakıf University Faculty of Medicine Hospital, Clinic of Gynecology and Obstetrics, İstanbul, Turkey Bezmialem Vakıf University Faculty of Medicine Hospital, Clinic of Gynecology and Obstetrics, İstanbul, Turkey Bezmialem Vakıf University Faculty of Medicine Hospital, Clinic of Gynecology and Obstetrics, İstanbul, Turkey İstanbul Training and Research Hospital, Clinic of Gynecology and Obstetrics, İstanbul, Turkey Bezmialem Vakıf University Faculty of Medicine Hospital, Clinic of Biostatistics, İstanbul, Turkey Aim:To assess the risk factors associated with high rate of insufficient endometrial sampling on endometrial biopsy in postmenopausal women.Methods:Data were retrieved from the records of 522 consecutive patients who underwent endometrial sampling. Logistic regression analyses were performed to determine various factors associated with scanty endometrial biopsy. The exclusion criteria included patient refusal, uncertain menopausal status, cervical carcinoma detected after sampling and unavailable records.Results:The sample was insufficient for a definitive diagnosis in 143 (25.9%) patients. Out of these, 53 cases were investigated with invasive procedures. Further histopathological examination revealed that five (9.4%) patients had uterine malignancy. Based on the multivariate analysis, time since the onset of menopause [Odds ratio (OR)=1.044, 95% confidence interval (CI)=1.000-1.090, p=0.049] was significantly associated with insufficient endometrial biopsy in cases with a endometrial thickness of >12 mm on ultrasonography (OR=0.624, 95% CI=0.472-0.824, p=0.001). The use of dilation and curettage technique (OR=0.662, 95% CI=0.522-0.841, p=0.001) decreased the risk of insufficient sampling on endometrial biopsy.Conclusion:Time since the onset of menopause and the thickness of endometrium were significant independent factors associated with insufficient sample. Using Karman cannula for endometrial aspiration may not be a reliable method in the evaluation of postmenopausal women. An insufficient endometrial sample does not rule out endometrial carcinoma, therefore, a further histopathological examination is recommended. http://www.hasekidergisi.com/archives/archive-detail/article-preview/factors-associated-with-nsufficient-endometrial-sa/35946 endometrial samplinginsufficient tissuedilation and curettageaspiration biopsyendometrial carcinoma |
| spellingShingle | Seda Ateş Ayşe Filiz Gökmen Karasu Halime Çalı Zeynep Soyman Ömer Uysal Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women Haseki Tıp Bülteni endometrial sampling insufficient tissue dilation and curettage aspiration biopsy endometrial carcinoma |
| title | Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women |
| title_full | Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women |
| title_fullStr | Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women |
| title_full_unstemmed | Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women |
| title_short | Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women |
| title_sort | factors associated with insufficient endometrial sampling in postmenopausal women |
| topic | endometrial sampling insufficient tissue dilation and curettage aspiration biopsy endometrial carcinoma |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/factors-associated-with-nsufficient-endometrial-sa/35946
|
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