De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
Adipocyte hyperplasia is thought to have beneficial metabolic effects in obesity, but definitive evidence is lacking. Here, Shao et al. promote de novo formation of adipocytes in visceral white adipose tissue (WAT) of adult mice through inducible overexpression of Pparg in Pdgfrβ+ preadipocytes and...
Full description
Bibliographic Details
| Main Authors: |
Mengle Shao,
Lavanya Vishvanath,
Napoleon C. Busbuso,
Chelsea Hepler,
Bo Shan,
Ankit X. Sharma,
Shiuhwei Chen,
Xinxin Yu,
Yu A. An,
Yi Zhu,
William L. Holland,
Rana K. Gupta |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2018-03-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-018-03196-x
|
|---|