Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development
The neurological complications of infection by the mosquito-borne Zika virus (ZIKV) include Guillain–Barré syndrome (GBS), an acute inflammatory demyelinating polyneuritis. GBS was first associated with recent ZIKV epidemics caused by the emergence of the ZIKV Asian lineage in South Pacific. Here, w...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/3/283 |
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| author | Grégorie Lebeau Etienne Frumence Jonathan Turpin Floran Begue Jean-Jacques Hoarau Gilles Gadea Pascale Krejbich-Trotot Philippe Desprès Wildriss Viranaicken |
| author_facet | Grégorie Lebeau Etienne Frumence Jonathan Turpin Floran Begue Jean-Jacques Hoarau Gilles Gadea Pascale Krejbich-Trotot Philippe Desprès Wildriss Viranaicken |
| author_sort | Grégorie Lebeau |
| collection | DOAJ |
| description | The neurological complications of infection by the mosquito-borne Zika virus (ZIKV) include Guillain–Barré syndrome (GBS), an acute inflammatory demyelinating polyneuritis. GBS was first associated with recent ZIKV epidemics caused by the emergence of the ZIKV Asian lineage in South Pacific. Here, we hypothesize that ZIKV-associated GBS relates to a molecular mimicry between viral envelope E (E) protein and neural proteins involved in GBS. The analysis of the ZIKV epidemic strains showed that the glycan loop (GL) region of the E protein includes an IVNDT motif which is conserved in voltage-dependent L-type calcium channel subunit alpha-1C (Ca<sub>v</sub>1.2) and Heat Shock 70 kDa protein 12A (HSP70 12A). Both VSCC-alpha 1C and HSP70 12A belong to protein families which have been associated with neurological autoimmune diseases in central nervous system. The purpose of our <i>in silico</i> analysis is to point out that IVNDT motif of ZIKV E-GL region should be taken in consideration for the development of safe and effective anti-Zika vaccines by precluding the possibility of adverse neurologic events including autoimmune diseases such as GBS through a potent mimicry with Heat Shock 70 kDa protein 12A (HSP70 12A). |
| first_indexed | 2024-03-10T13:04:51Z |
| format | Article |
| id | doaj.art-6cc82d5b5f5f4b2982307ed05fc93164 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T13:04:51Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-6cc82d5b5f5f4b2982307ed05fc931642023-11-21T11:10:49ZengMDPI AGVaccines2076-393X2021-03-019328310.3390/vaccines9030283Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine DevelopmentGrégorie Lebeau0Etienne Frumence1Jonathan Turpin2Floran Begue3Jean-Jacques Hoarau4Gilles Gadea5Pascale Krejbich-Trotot6Philippe Desprès7Wildriss Viranaicken8Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Université de La Réunion 1, La Réunion, 97490 Sainte-Clotilde, FranceProcessus Infectieux en Milieu Insulaire et Tropical (PIMIT), Université de La Réunion 1, La Réunion, 97490 Sainte-Clotilde, FranceProcessus Infectieux en Milieu Insulaire et Tropical (PIMIT), Université de La Réunion 1, La Réunion, 97490 Sainte-Clotilde, FranceUniversité de La Réunion, INSERM, UMR 1188 Diabète athérothombose Réunion Océan Indien (DéTROI), 97490 Saint-Clotilde, FranceProcessus Infectieux en Milieu Insulaire et Tropical (PIMIT), Université de La Réunion 1, La Réunion, 97490 Sainte-Clotilde, FranceProcessus Infectieux en Milieu Insulaire et Tropical (PIMIT), Université de La Réunion 1, La Réunion, 97490 Sainte-Clotilde, FranceProcessus Infectieux en Milieu Insulaire et Tropical (PIMIT), Université de La Réunion 1, La Réunion, 97490 Sainte-Clotilde, FranceProcessus Infectieux en Milieu Insulaire et Tropical (PIMIT), Université de La Réunion 1, La Réunion, 97490 Sainte-Clotilde, FranceProcessus Infectieux en Milieu Insulaire et Tropical (PIMIT), Université de La Réunion 1, La Réunion, 97490 Sainte-Clotilde, FranceThe neurological complications of infection by the mosquito-borne Zika virus (ZIKV) include Guillain–Barré syndrome (GBS), an acute inflammatory demyelinating polyneuritis. GBS was first associated with recent ZIKV epidemics caused by the emergence of the ZIKV Asian lineage in South Pacific. Here, we hypothesize that ZIKV-associated GBS relates to a molecular mimicry between viral envelope E (E) protein and neural proteins involved in GBS. The analysis of the ZIKV epidemic strains showed that the glycan loop (GL) region of the E protein includes an IVNDT motif which is conserved in voltage-dependent L-type calcium channel subunit alpha-1C (Ca<sub>v</sub>1.2) and Heat Shock 70 kDa protein 12A (HSP70 12A). Both VSCC-alpha 1C and HSP70 12A belong to protein families which have been associated with neurological autoimmune diseases in central nervous system. The purpose of our <i>in silico</i> analysis is to point out that IVNDT motif of ZIKV E-GL region should be taken in consideration for the development of safe and effective anti-Zika vaccines by precluding the possibility of adverse neurologic events including autoimmune diseases such as GBS through a potent mimicry with Heat Shock 70 kDa protein 12A (HSP70 12A).https://www.mdpi.com/2076-393X/9/3/283ZIKVGuillain–Barré syndromemolecular mimicrycalcium channel voltage dependentheat shock proteinvaccine |
| spellingShingle | Grégorie Lebeau Etienne Frumence Jonathan Turpin Floran Begue Jean-Jacques Hoarau Gilles Gadea Pascale Krejbich-Trotot Philippe Desprès Wildriss Viranaicken Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development Vaccines ZIKV Guillain–Barré syndrome molecular mimicry calcium channel voltage dependent heat shock protein vaccine |
| title | Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development |
| title_full | Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development |
| title_fullStr | Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development |
| title_full_unstemmed | Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development |
| title_short | Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development |
| title_sort | zika e glycan loop region and guillain barre syndrome related proteins a possible molecular mimicry to be taken in account for vaccine development |
| topic | ZIKV Guillain–Barré syndrome molecular mimicry calcium channel voltage dependent heat shock protein vaccine |
| url | https://www.mdpi.com/2076-393X/9/3/283 |
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