Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 Neurons
Competition between synapses contributes to activity-dependent refinement of the nervous system during development. Does local competition between neighboring synapses drive circuit remodeling during experience-dependent plasticity in the cerebral cortex? Here, we examined the role of activity-media...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-01-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124714010456 |
| _version_ | 1818204093946003456 |
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| author | Won Chan Oh Laxmi Kumar Parajuli Karen Zito |
| author_facet | Won Chan Oh Laxmi Kumar Parajuli Karen Zito |
| author_sort | Won Chan Oh |
| collection | DOAJ |
| description | Competition between synapses contributes to activity-dependent refinement of the nervous system during development. Does local competition between neighboring synapses drive circuit remodeling during experience-dependent plasticity in the cerebral cortex? Here, we examined the role of activity-mediated competitive interactions in regulating dendritic spine structure and function on hippocampal CA1 neurons. We found that high-frequency glutamatergic stimulation at individual spines, which leads to input-specific synaptic potentiation, induces shrinkage and weakening of nearby unstimulated synapses. This heterosynaptic plasticity requires potentiation of multiple neighboring spines, suggesting that a local threshold of neural activity exists beyond which inactive synapses are punished. Notably, inhibition of calcineurin, IP3Rs, or group I metabotropic glutamate receptors (mGluRs) blocked heterosynaptic shrinkage without blocking structural potentiation, and inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII) blocked structural potentiation without blocking heterosynaptic shrinkage. Our results support a model in which activity-induced shrinkage signal, and not competition for limited structural resources, drives heterosynaptic structural and functional depression during neural circuit refinement. |
| first_indexed | 2024-12-12T03:35:46Z |
| format | Article |
| id | doaj.art-6cca7c3ab7134e7187adc9759d59c518 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-12T03:35:46Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-6cca7c3ab7134e7187adc9759d59c5182022-12-22T00:39:49ZengElsevierCell Reports2211-12472015-01-0110216216910.1016/j.celrep.2014.12.016Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 NeuronsWon Chan Oh0Laxmi Kumar Parajuli1Karen Zito2Center for Neuroscience, University of California Davis, Davis, CA 95616, USACenter for Neuroscience, University of California Davis, Davis, CA 95616, USACenter for Neuroscience, University of California Davis, Davis, CA 95616, USACompetition between synapses contributes to activity-dependent refinement of the nervous system during development. Does local competition between neighboring synapses drive circuit remodeling during experience-dependent plasticity in the cerebral cortex? Here, we examined the role of activity-mediated competitive interactions in regulating dendritic spine structure and function on hippocampal CA1 neurons. We found that high-frequency glutamatergic stimulation at individual spines, which leads to input-specific synaptic potentiation, induces shrinkage and weakening of nearby unstimulated synapses. This heterosynaptic plasticity requires potentiation of multiple neighboring spines, suggesting that a local threshold of neural activity exists beyond which inactive synapses are punished. Notably, inhibition of calcineurin, IP3Rs, or group I metabotropic glutamate receptors (mGluRs) blocked heterosynaptic shrinkage without blocking structural potentiation, and inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII) blocked structural potentiation without blocking heterosynaptic shrinkage. Our results support a model in which activity-induced shrinkage signal, and not competition for limited structural resources, drives heterosynaptic structural and functional depression during neural circuit refinement.http://www.sciencedirect.com/science/article/pii/S2211124714010456 |
| spellingShingle | Won Chan Oh Laxmi Kumar Parajuli Karen Zito Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 Neurons Cell Reports |
| title | Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 Neurons |
| title_full | Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 Neurons |
| title_fullStr | Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 Neurons |
| title_full_unstemmed | Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 Neurons |
| title_short | Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 Neurons |
| title_sort | heterosynaptic structural plasticity on local dendritic segments of hippocampal ca1 neurons |
| url | http://www.sciencedirect.com/science/article/pii/S2211124714010456 |
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