Terapêutica hormonal de subtituição e cancro da mama. 2. A mulher com cancro da mama deve receber terapêutica hormonal de substituição?
The common menopausal symptoms of a growing number of women treated for breast cancer poses difficult therapeutic decisions to the Gynaecologist. It has been extensively demonstrated that hormonal replacement therapy (HRT) is the most effective treatment of such symptoms, as well as protecting women...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
1997-10-01
|
| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2472 |
| _version_ | 1828106252385779712 |
|---|---|
| author | D Ayres de Campos M J Cardoso J Martinez de Oliveira |
| author_facet | D Ayres de Campos M J Cardoso J Martinez de Oliveira |
| author_sort | D Ayres de Campos |
| collection | DOAJ |
| description | The common menopausal symptoms of a growing number of women treated for breast cancer poses difficult therapeutic decisions to the Gynaecologist. It has been extensively demonstrated that hormonal replacement therapy (HRT) is the most effective treatment of such symptoms, as well as protecting women from cardiovascular disease, osteoporosis and increased mortality related to these disorders. However, breast cancer is classically considered a contraindication to HRT. In this paper we review the existing evidence regarding the influence of HRT on breast cancer. A computerized bibliographical search (MEDLINE) of literature in the English-language literature published in the last 15 years was conducted, followed by a hand search of references found in these papers. Evidence on the response of breast cancer cells to HRT is derived from animal studies, tissue growth system experiments, indirect epidemiological data and clinical data. While the bulk of experimental evidence points towards a proliferative effect of estrogen on breast cancer cells, almost all clinical reports have found no adverse effects of HRT on these patients. In our opinion, currently existing evidence does not justify the denial of HRT to breast cancer patients whose quality of life is at stake. Such is the case of women with intense menopausal symptoms unresponsive to alternative therapies. This opinion is shared by numerous other authors and a small number of eminent institutions. We believe it is safer to avoid HRT, in asymptomatic women as long-term regimens would be needed for protection against cardiovascular disease and osteoporosis, and the risks of such regimens have yet to be evaluated. We also believe that large randomized trials are now ethically justified and greatly needed to obtain safer data on this subject. |
| first_indexed | 2024-04-11T10:13:57Z |
| format | Article |
| id | doaj.art-6ccb5a8bd4e049c39688c290d4159511 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-11T10:13:57Z |
| publishDate | 1997-10-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-6ccb5a8bd4e049c39688c290d41595112022-12-22T04:30:01ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581997-10-01101010.20344/amp.2472Terapêutica hormonal de subtituição e cancro da mama. 2. A mulher com cancro da mama deve receber terapêutica hormonal de substituição?D Ayres de Campos0M J CardosoJ Martinez de OliveiraDepartamento de Ginecologia e Obstetrícia, Hospital de São João, Faculdade de Medicina do Porto.The common menopausal symptoms of a growing number of women treated for breast cancer poses difficult therapeutic decisions to the Gynaecologist. It has been extensively demonstrated that hormonal replacement therapy (HRT) is the most effective treatment of such symptoms, as well as protecting women from cardiovascular disease, osteoporosis and increased mortality related to these disorders. However, breast cancer is classically considered a contraindication to HRT. In this paper we review the existing evidence regarding the influence of HRT on breast cancer. A computerized bibliographical search (MEDLINE) of literature in the English-language literature published in the last 15 years was conducted, followed by a hand search of references found in these papers. Evidence on the response of breast cancer cells to HRT is derived from animal studies, tissue growth system experiments, indirect epidemiological data and clinical data. While the bulk of experimental evidence points towards a proliferative effect of estrogen on breast cancer cells, almost all clinical reports have found no adverse effects of HRT on these patients. In our opinion, currently existing evidence does not justify the denial of HRT to breast cancer patients whose quality of life is at stake. Such is the case of women with intense menopausal symptoms unresponsive to alternative therapies. This opinion is shared by numerous other authors and a small number of eminent institutions. We believe it is safer to avoid HRT, in asymptomatic women as long-term regimens would be needed for protection against cardiovascular disease and osteoporosis, and the risks of such regimens have yet to be evaluated. We also believe that large randomized trials are now ethically justified and greatly needed to obtain safer data on this subject.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2472 |
| spellingShingle | D Ayres de Campos M J Cardoso J Martinez de Oliveira Terapêutica hormonal de subtituição e cancro da mama. 2. A mulher com cancro da mama deve receber terapêutica hormonal de substituição? Acta Médica Portuguesa |
| title | Terapêutica hormonal de subtituição e cancro da mama. 2. A mulher com cancro da mama deve receber terapêutica hormonal de substituição? |
| title_full | Terapêutica hormonal de subtituição e cancro da mama. 2. A mulher com cancro da mama deve receber terapêutica hormonal de substituição? |
| title_fullStr | Terapêutica hormonal de subtituição e cancro da mama. 2. A mulher com cancro da mama deve receber terapêutica hormonal de substituição? |
| title_full_unstemmed | Terapêutica hormonal de subtituição e cancro da mama. 2. A mulher com cancro da mama deve receber terapêutica hormonal de substituição? |
| title_short | Terapêutica hormonal de subtituição e cancro da mama. 2. A mulher com cancro da mama deve receber terapêutica hormonal de substituição? |
| title_sort | terapeutica hormonal de subtituicao e cancro da mama 2 a mulher com cancro da mama deve receber terapeutica hormonal de substituicao |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2472 |
| work_keys_str_mv | AT dayresdecampos terapeuticahormonaldesubtituicaoecancrodamama2amulhercomcancrodamamadevereceberterapeuticahormonaldesubstituicao AT mjcardoso terapeuticahormonaldesubtituicaoecancrodamama2amulhercomcancrodamamadevereceberterapeuticahormonaldesubstituicao AT jmartinezdeoliveira terapeuticahormonaldesubtituicaoecancrodamama2amulhercomcancrodamamadevereceberterapeuticahormonaldesubstituicao |