Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected?
Background: The effective immunization of healthcare workers (HCWs) plays a vital role in preventing the spread of SARS-CoV-2 infection during the coronavirus disease 2019 (COVID-19) pandemic. There is limited data on the immune response to vaccination among HCWs. We aim to determine seroprevalence...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/5/642 |
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| author | Lina Souan Maher A. Sughayer Maha M. Abualhour Mahmoud Siag Sara Al-Badr Tareq Al-Atrash |
| author_facet | Lina Souan Maher A. Sughayer Maha M. Abualhour Mahmoud Siag Sara Al-Badr Tareq Al-Atrash |
| author_sort | Lina Souan |
| collection | DOAJ |
| description | Background: The effective immunization of healthcare workers (HCWs) plays a vital role in preventing the spread of SARS-CoV-2 infection during the coronavirus disease 2019 (COVID-19) pandemic. There is limited data on the immune response to vaccination among HCWs. We aim to determine seroprevalence rates and neutralizing IgG antibody response to various immunizations among HCWs. Methods: This study was conducted between July and September 2021, in which blood samples were obtained from HCWs and SARS-CoV-2 IgG neutralizing antibodies were measured. Data regarding vaccination status with Pfizer/BioNTech, Sinopharm, or AstraZeneca vaccines, occupation, and prior COVID-19 infection were analyzed. Results: COVID-19 infection post-vaccination was associated with higher mean antibody titers, regardless of vaccine type. Pfizer/BioNTech vaccination produced higher mean antibody titers for HCWs with prior COVID-19 infection (<i>p</i> < 0.00001) than other types of vaccines. Although 96% of HCWs were vaccinated, 3% were seronegative. For HCWs who were seropositive, there were no significant differences between the mean antibody titers when comparing occupations and blood indices. Conclusion: Awareness of the immunity status of HCWs is key to protecting this important group against SARS-CoV-2, especially those without prior COVID-19 infection. Further public health efforts regarding booster vaccination for HCWs are crucial to provide necessary antibody protection. |
| first_indexed | 2024-03-10T01:40:23Z |
| format | Article |
| id | doaj.art-6ccbd5f4a85949b09af07f6fcd314ec1 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T01:40:23Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-6ccbd5f4a85949b09af07f6fcd314ec12023-11-23T13:24:47ZengMDPI AGVaccines2076-393X2022-04-0110564210.3390/vaccines10050642Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected?Lina Souan0Maher A. Sughayer1Maha M. Abualhour2Mahmoud Siag3Sara Al-Badr4Tareq Al-Atrash5Department of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman 11941, JordanDepartment of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman 11941, JordanDepartment of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman 11941, JordanDepartment of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman 11941, JordanDepartment of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman 11941, JordanDepartment of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman 11941, JordanBackground: The effective immunization of healthcare workers (HCWs) plays a vital role in preventing the spread of SARS-CoV-2 infection during the coronavirus disease 2019 (COVID-19) pandemic. There is limited data on the immune response to vaccination among HCWs. We aim to determine seroprevalence rates and neutralizing IgG antibody response to various immunizations among HCWs. Methods: This study was conducted between July and September 2021, in which blood samples were obtained from HCWs and SARS-CoV-2 IgG neutralizing antibodies were measured. Data regarding vaccination status with Pfizer/BioNTech, Sinopharm, or AstraZeneca vaccines, occupation, and prior COVID-19 infection were analyzed. Results: COVID-19 infection post-vaccination was associated with higher mean antibody titers, regardless of vaccine type. Pfizer/BioNTech vaccination produced higher mean antibody titers for HCWs with prior COVID-19 infection (<i>p</i> < 0.00001) than other types of vaccines. Although 96% of HCWs were vaccinated, 3% were seronegative. For HCWs who were seropositive, there were no significant differences between the mean antibody titers when comparing occupations and blood indices. Conclusion: Awareness of the immunity status of HCWs is key to protecting this important group against SARS-CoV-2, especially those without prior COVID-19 infection. Further public health efforts regarding booster vaccination for HCWs are crucial to provide necessary antibody protection.https://www.mdpi.com/2076-393X/10/5/642COVID-19SARS-CoV-2antibody titerneutralizing antibodyIgGhealthcare workers |
| spellingShingle | Lina Souan Maher A. Sughayer Maha M. Abualhour Mahmoud Siag Sara Al-Badr Tareq Al-Atrash Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected? Vaccines COVID-19 SARS-CoV-2 antibody titer neutralizing antibody IgG healthcare workers |
| title | Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected? |
| title_full | Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected? |
| title_fullStr | Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected? |
| title_full_unstemmed | Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected? |
| title_short | Comparison of the Immunogenicity and Protective Efficacy of Various SARS-CoV-2 Vaccines among Healthcare Workers: Are Our White Coat Armies Protected? |
| title_sort | comparison of the immunogenicity and protective efficacy of various sars cov 2 vaccines among healthcare workers are our white coat armies protected |
| topic | COVID-19 SARS-CoV-2 antibody titer neutralizing antibody IgG healthcare workers |
| url | https://www.mdpi.com/2076-393X/10/5/642 |
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