Minocycline-induced transient depersonalization: A case report
Minocycline is a medication commonly used for the treatment of acne vulgaris. The central nervous system-induced side effects of minocycline include headaches, pseudotumor cerebri, ataxia, and vestibular dysfunction. Many minocycline-related side effects have been presented in the literature, howeve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-01-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X18823827 |
| _version_ | 1818922823064748032 |
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| author | Yassein Shamout Alissa Sigal Ivan V Litvinov |
| author_facet | Yassein Shamout Alissa Sigal Ivan V Litvinov |
| author_sort | Yassein Shamout |
| collection | DOAJ |
| description | Minocycline is a medication commonly used for the treatment of acne vulgaris. The central nervous system-induced side effects of minocycline include headaches, pseudotumor cerebri, ataxia, and vestibular dysfunction. Many minocycline-related side effects have been presented in the literature, however, reports of depersonalization symptoms induced by the medication are rare. We present the case of a 37-year-old female diagnosed with perioral dermatitis treated with minocycline, who within 1 week suffered from severe depersonalization symptoms. The pathophysiologic mechanism of depersonalization induced by minocycline is unclear but various hypotheses include hypersensitivity of the serotonin system, drug-related metabolic encephalopathy, substance-induced temporal disintegration, and panic-disorder-related etiology. Depersonalization is a potentially severe and important side effect of minocycline that should be documented, further investigated, and recognized by clinicians. |
| first_indexed | 2024-12-20T01:59:39Z |
| format | Article |
| id | doaj.art-6ccfc1a899cb4f779bba0f916d21f109 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-20T01:59:39Z |
| publishDate | 2019-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-6ccfc1a899cb4f779bba0f916d21f1092022-12-21T19:57:23ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2019-01-01710.1177/2050313X18823827Minocycline-induced transient depersonalization: A case reportYassein Shamout0Alissa Sigal1Ivan V Litvinov2Division of Dermatology, McGill University, Montreal, QC, CanadaFaculty of Medicine, Université de Montréal, Montreal, QC, CanadaDivision of Dermatology, McGill University, Montreal, QC, CanadaMinocycline is a medication commonly used for the treatment of acne vulgaris. The central nervous system-induced side effects of minocycline include headaches, pseudotumor cerebri, ataxia, and vestibular dysfunction. Many minocycline-related side effects have been presented in the literature, however, reports of depersonalization symptoms induced by the medication are rare. We present the case of a 37-year-old female diagnosed with perioral dermatitis treated with minocycline, who within 1 week suffered from severe depersonalization symptoms. The pathophysiologic mechanism of depersonalization induced by minocycline is unclear but various hypotheses include hypersensitivity of the serotonin system, drug-related metabolic encephalopathy, substance-induced temporal disintegration, and panic-disorder-related etiology. Depersonalization is a potentially severe and important side effect of minocycline that should be documented, further investigated, and recognized by clinicians.https://doi.org/10.1177/2050313X18823827 |
| spellingShingle | Yassein Shamout Alissa Sigal Ivan V Litvinov Minocycline-induced transient depersonalization: A case report SAGE Open Medical Case Reports |
| title | Minocycline-induced transient depersonalization: A case report |
| title_full | Minocycline-induced transient depersonalization: A case report |
| title_fullStr | Minocycline-induced transient depersonalization: A case report |
| title_full_unstemmed | Minocycline-induced transient depersonalization: A case report |
| title_short | Minocycline-induced transient depersonalization: A case report |
| title_sort | minocycline induced transient depersonalization a case report |
| url | https://doi.org/10.1177/2050313X18823827 |
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