Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia
ABSTRACTChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2276490 |
| _version_ | 1797367122288967680 |
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| author | Iria Fernandez Botana Giulia Pagano Etienne Moussay Jerome Paggetti |
| author_facet | Iria Fernandez Botana Giulia Pagano Etienne Moussay Jerome Paggetti |
| author_sort | Iria Fernandez Botana |
| collection | DOAJ |
| description | ABSTRACTChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism. |
| first_indexed | 2024-03-08T17:12:50Z |
| format | Article |
| id | doaj.art-6ccff743e491466b95b6ae76421016ba |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-03-08T17:12:50Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-6ccff743e491466b95b6ae76421016ba2024-01-03T19:25:36ZengTaylor & Francis GroupOncoImmunology2162-402X2023-12-0112110.1080/2162402X.2023.2276490Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemiaIria Fernandez Botana0Giulia Pagano1Etienne Moussay2Jerome Paggetti3Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, LuxembourgTumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, LuxembourgTumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, LuxembourgTumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, LuxembourgABSTRACTChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.https://www.tandfonline.com/doi/10.1080/2162402X.2023.2276490CytokineIL-27CD8+ T cellsimmunotherapyleukemia |
| spellingShingle | Iria Fernandez Botana Giulia Pagano Etienne Moussay Jerome Paggetti Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia OncoImmunology Cytokine IL-27 CD8+ T cells immunotherapy leukemia |
| title | Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia |
| title_full | Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia |
| title_fullStr | Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia |
| title_full_unstemmed | Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia |
| title_short | Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia |
| title_sort | interleukin 27 tackles immunosuppression in chronic lymphocytic leukemia |
| topic | Cytokine IL-27 CD8+ T cells immunotherapy leukemia |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2276490 |
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