The Chronic Effects of a Single Low-Intensity Blast Exposure on Phosphoproteome Networks and Cognitive Function Influenced by Mutant Tau Overexpression

The Chronic Effects of a Single Low-Intensity Blast Exposure on Phosphoproteome Networks and Cognitive Function Influenced by Mutant Tau Overexpression

Blast-induced neurotrauma (BINT) is a pressing concern for veterans and civilians exposed to explosive devices. Affected personnel may have increased risk for long-term cognitive decline and developing tauopathies including Alzheimer’s disease-related disorders (ADRD) or frontal-temporal dementia (F...

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Bibliographic Details
Main Authors: Marcus Jackson, Shanyan Chen, Thao Thi Nguyen, Heather R. Siedhoff, Ashley Balderrama, Amitai Zuckerman, Runting Li, C. Michael Greenlief, Gregory Cole, Sally A. Frautschy, Jiankun Cui, Zezong Gu
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
low-intensity open-field blast
discrimination-learning index
phosphopeptides
label-free DIA-PASEF quantitative proteomics
phosphoproteomic profiling
WpCNA
Online Access:https://www.mdpi.com/1422-0067/25/6/3338

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