Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD)

Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD)

<p>Abstract</p> <p>Background</p> <p><it>TP53 </it>is an attractive candidate for modifying age of onset (AO) in Huntington disease (HD): The amino-terminus of the mutated huntingtin (htt) exon 1 translation product has functional properties which may affect...

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Bibliographic Details
Main Authors: Andrich Jürgen, Saft Carsten, Kraus Peter H, Arning Larissa, Epplen Jörg T
Format: Article
Language:English
Published: BMC 2005-10-01
Series:BMC Medical Genetics
Online Access:http://www.biomedcentral.com/1471-2350/6/35

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