Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling
ARMMs are extracellular vesicles that bud directly at the plasma membrane; their function is poorly understood. Here the authors purify and carryout a proteomics analysis of the protein components of ARMMs, and show that NOTCH receptors are recruited into ARMMs and can be transferred to recipient ce...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00767-2 |
| _version_ | 1818400470254747648 |
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| author | Qiyu Wang Quan Lu |
| author_facet | Qiyu Wang Quan Lu |
| author_sort | Qiyu Wang |
| collection | DOAJ |
| description | ARMMs are extracellular vesicles that bud directly at the plasma membrane; their function is poorly understood. Here the authors purify and carryout a proteomics analysis of the protein components of ARMMs, and show that NOTCH receptors are recruited into ARMMs and can be transferred to recipient cells to mediate NOTCH signaling. |
| first_indexed | 2024-12-14T07:37:05Z |
| format | Article |
| id | doaj.art-6cd303323cdc4b21a1380570c3dfea21 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:37:05Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6cd303323cdc4b21a1380570c3dfea212022-12-21T23:11:10ZengNature PortfolioNature Communications2041-17232017-09-01811910.1038/s41467-017-00767-2Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signalingQiyu Wang0Quan Lu1Program in Molecular and Integrative Physiological Sciences, Department of Environment Health, Harvard T.H. Chan School of Public HealthProgram in Molecular and Integrative Physiological Sciences, Department of Environment Health, Harvard T.H. Chan School of Public HealthARMMs are extracellular vesicles that bud directly at the plasma membrane; their function is poorly understood. Here the authors purify and carryout a proteomics analysis of the protein components of ARMMs, and show that NOTCH receptors are recruited into ARMMs and can be transferred to recipient cells to mediate NOTCH signaling.https://doi.org/10.1038/s41467-017-00767-2 |
| spellingShingle | Qiyu Wang Quan Lu Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling Nature Communications |
| title | Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling |
| title_full | Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling |
| title_fullStr | Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling |
| title_full_unstemmed | Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling |
| title_short | Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling |
| title_sort | plasma membrane derived extracellular microvesicles mediate non canonical intercellular notch signaling |
| url | https://doi.org/10.1038/s41467-017-00767-2 |
| work_keys_str_mv | AT qiyuwang plasmamembranederivedextracellularmicrovesiclesmediatenoncanonicalintercellularnotchsignaling AT quanlu plasmamembranederivedextracellularmicrovesiclesmediatenoncanonicalintercellularnotchsignaling |