An Evaluation of Programmatic Community-Based Chest X-ray Screening for Tuberculosis in Ho Chi Minh City, Vietnam
Across Asia, a large proportion of people with tuberculosis (TB) do not report symptoms, have mild symptoms or only experience symptoms for a short duration. These individuals may not seek care at health facilities or may be missed by symptom screening, resulting in sustained TB transmission in the...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/5/4/185 |
| _version_ | 1797545172645445632 |
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| author | Lan Huu Nguyen Andrew J. Codlin Luan Nguyen Quang Vo Thang Dao Duc Tran Rachel J. Forse Thanh Nguyen Vu Giang Truong Le Tuan Luu Giang Chau Do Vinh Van Truong Ha Dang Thi Minh Hung Huu Nguyen Jacob Creswell Maxine Caws Hoa Binh Nguyen Nhung Viet Nguyen |
| author_facet | Lan Huu Nguyen Andrew J. Codlin Luan Nguyen Quang Vo Thang Dao Duc Tran Rachel J. Forse Thanh Nguyen Vu Giang Truong Le Tuan Luu Giang Chau Do Vinh Van Truong Ha Dang Thi Minh Hung Huu Nguyen Jacob Creswell Maxine Caws Hoa Binh Nguyen Nhung Viet Nguyen |
| author_sort | Lan Huu Nguyen |
| collection | DOAJ |
| description | Across Asia, a large proportion of people with tuberculosis (TB) do not report symptoms, have mild symptoms or only experience symptoms for a short duration. These individuals may not seek care at health facilities or may be missed by symptom screening, resulting in sustained TB transmission in the community. We evaluated the yields of TB from 114 days of community-based, mobile chest X-ray (CXR) screening. The yields at each step of the TB screening cascade were tabulated and we compared cohorts of participants who reported having a prolonged cough and those reporting no cough or one of short duration. We estimated the marginal yields of TB using different diagnostic algorithms and calculated the relative diagnostic costs and cost per case for each algorithm. A total of 34,529 participants were screened by CXR, detecting 256 people with Xpert-positive TB. Only 50% of those diagnosed with TB were detected among participants reporting a prolonged cough. The study’s screening algorithm detected almost 4 times as much TB as the National TB Program’s standard diagnostic algorithm. Community-based, mobile chest X-ray screening can be a high yielding strategy which is able to identify people with TB who would likely otherwise have been missed by existing health services. |
| first_indexed | 2024-03-10T14:11:43Z |
| format | Article |
| id | doaj.art-6cd7a3ff06db45c2bdcb529382a8695b |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T14:11:43Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-6cd7a3ff06db45c2bdcb529382a8695b2023-11-21T00:06:50ZengMDPI AGTropical Medicine and Infectious Disease2414-63662020-12-015418510.3390/tropicalmed5040185An Evaluation of Programmatic Community-Based Chest X-ray Screening for Tuberculosis in Ho Chi Minh City, VietnamLan Huu Nguyen0Andrew J. Codlin1Luan Nguyen Quang Vo2Thang Dao3Duc Tran4Rachel J. Forse5Thanh Nguyen Vu6Giang Truong Le7Tuan Luu8Giang Chau Do9Vinh Van Truong10Ha Dang Thi Minh11Hung Huu Nguyen12Jacob Creswell13Maxine Caws14Hoa Binh Nguyen15Nhung Viet Nguyen16Pham Ngoc Thach Hospital, Ho Chi Minh City 700 000, VietnamFriends for International TB Relief, Ho Chi Minh City 700 000, VietnamFriends for International TB Relief, Ho Chi Minh City 700 000, VietnamIRD VN, Ho Chi Minh City 700 000, VietnamFriends for International TB Relief, Ho Chi Minh City 700 000, VietnamFriends for International TB Relief, Ho Chi Minh City 700 000, VietnamHo Chi Minh City Public Health Association, Ho Chi Minh City 700 000, VietnamHo Chi Minh City Public Health Association, Ho Chi Minh City 700 000, VietnamClinton Health Access Initiative Vietnam, Ha Noi 100 000, VietnamPham Ngoc Thach Hospital, Ho Chi Minh City 700 000, VietnamPham Ngoc Thach Hospital, Ho Chi Minh City 700 000, VietnamPham Ngoc Thach Hospital, Ho Chi Minh City 700 000, VietnamHo Chi Minh City Department of Health, Ho Chi Minh City 700 000, VietnamStop TB Partnership, 1218 Geneva, SwitzerlandDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UKViet Nam National Lung Hospital, Ha Noi 100 000, VietnamViet Nam National Lung Hospital, Ha Noi 100 000, VietnamAcross Asia, a large proportion of people with tuberculosis (TB) do not report symptoms, have mild symptoms or only experience symptoms for a short duration. These individuals may not seek care at health facilities or may be missed by symptom screening, resulting in sustained TB transmission in the community. We evaluated the yields of TB from 114 days of community-based, mobile chest X-ray (CXR) screening. The yields at each step of the TB screening cascade were tabulated and we compared cohorts of participants who reported having a prolonged cough and those reporting no cough or one of short duration. We estimated the marginal yields of TB using different diagnostic algorithms and calculated the relative diagnostic costs and cost per case for each algorithm. A total of 34,529 participants were screened by CXR, detecting 256 people with Xpert-positive TB. Only 50% of those diagnosed with TB were detected among participants reporting a prolonged cough. The study’s screening algorithm detected almost 4 times as much TB as the National TB Program’s standard diagnostic algorithm. Community-based, mobile chest X-ray screening can be a high yielding strategy which is able to identify people with TB who would likely otherwise have been missed by existing health services.https://www.mdpi.com/2414-6366/5/4/185tuberculosisTBchest X-rayactive TB case-findingdiagnostic algorithm |
| spellingShingle | Lan Huu Nguyen Andrew J. Codlin Luan Nguyen Quang Vo Thang Dao Duc Tran Rachel J. Forse Thanh Nguyen Vu Giang Truong Le Tuan Luu Giang Chau Do Vinh Van Truong Ha Dang Thi Minh Hung Huu Nguyen Jacob Creswell Maxine Caws Hoa Binh Nguyen Nhung Viet Nguyen An Evaluation of Programmatic Community-Based Chest X-ray Screening for Tuberculosis in Ho Chi Minh City, Vietnam Tropical Medicine and Infectious Disease tuberculosis TB chest X-ray active TB case-finding diagnostic algorithm |
| title | An Evaluation of Programmatic Community-Based Chest X-ray Screening for Tuberculosis in Ho Chi Minh City, Vietnam |
| title_full | An Evaluation of Programmatic Community-Based Chest X-ray Screening for Tuberculosis in Ho Chi Minh City, Vietnam |
| title_fullStr | An Evaluation of Programmatic Community-Based Chest X-ray Screening for Tuberculosis in Ho Chi Minh City, Vietnam |
| title_full_unstemmed | An Evaluation of Programmatic Community-Based Chest X-ray Screening for Tuberculosis in Ho Chi Minh City, Vietnam |
| title_short | An Evaluation of Programmatic Community-Based Chest X-ray Screening for Tuberculosis in Ho Chi Minh City, Vietnam |
| title_sort | evaluation of programmatic community based chest x ray screening for tuberculosis in ho chi minh city vietnam |
| topic | tuberculosis TB chest X-ray active TB case-finding diagnostic algorithm |
| url | https://www.mdpi.com/2414-6366/5/4/185 |
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