Turnover of cholesterol-4-14C and cholic acid-24-14C by rabbits fed a diet containing lactose
Rabbits fed 0.35% of cholesterol in diets containing either 29.35% of lactose or sucrose were studied for 14 weeks. The rabbits fed lactose had higher plasma and liver cholesterol concentrations than those fed sucrose. The half-life of cholesterol was 19.0 days and 35.0 days for rabbits fed sucrose...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1966-05-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520389641 |
| _version_ | 1818728832709951488 |
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| author | N. Iritani W.W. Wells |
| author_facet | N. Iritani W.W. Wells |
| author_sort | N. Iritani |
| collection | DOAJ |
| description | Rabbits fed 0.35% of cholesterol in diets containing either 29.35% of lactose or sucrose were studied for 14 weeks. The rabbits fed lactose had higher plasma and liver cholesterol concentrations than those fed sucrose. The half-life of cholesterol was 19.0 days and 35.0 days for rabbits fed sucrose and lactose, respectively. The half-life, pool size, and daily production of deoxycholic acid were 9.7 days, 1.29 g, and 74.1 mg for rabbits fed sucrose; and 14.2 days, 1.40 g, and 49.1 mg, for those fed lactose. Cholesterol was the major neutral sterol in the feces of the rabbits fed lactose, whereas coprostanol (5Β-cholestan-3Β-ol) dominated the corresponding fraction in those fed sucrose.The fecal steroid composition did not vary between day and night collections. No sterol esters were detected in the feces. Urinary elimination of radioactivity was less than 10% of that injected.The ``lactose effect'' seems to be due to enhanced retention of steroids, the mechanism of which has not been elucidated. |
| first_indexed | 2024-12-17T22:36:16Z |
| format | Article |
| id | doaj.art-6cd9c57e83f3432793946d046730b8d6 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T22:36:16Z |
| publishDate | 1966-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-6cd9c57e83f3432793946d046730b8d62022-12-21T21:30:05ZengElsevierJournal of Lipid Research0022-22751966-05-0173372378Turnover of cholesterol-4-14C and cholic acid-24-14C by rabbits fed a diet containing lactoseN. Iritani0W.W. Wells1Biochemistry Department, School of Medicine, University of Pittsburgh, Pittsburgh, PennsylvaniaBiochemistry Department, School of Medicine, University of Pittsburgh, Pittsburgh, PennsylvaniaRabbits fed 0.35% of cholesterol in diets containing either 29.35% of lactose or sucrose were studied for 14 weeks. The rabbits fed lactose had higher plasma and liver cholesterol concentrations than those fed sucrose. The half-life of cholesterol was 19.0 days and 35.0 days for rabbits fed sucrose and lactose, respectively. The half-life, pool size, and daily production of deoxycholic acid were 9.7 days, 1.29 g, and 74.1 mg for rabbits fed sucrose; and 14.2 days, 1.40 g, and 49.1 mg, for those fed lactose. Cholesterol was the major neutral sterol in the feces of the rabbits fed lactose, whereas coprostanol (5Β-cholestan-3Β-ol) dominated the corresponding fraction in those fed sucrose.The fecal steroid composition did not vary between day and night collections. No sterol esters were detected in the feces. Urinary elimination of radioactivity was less than 10% of that injected.The ``lactose effect'' seems to be due to enhanced retention of steroids, the mechanism of which has not been elucidated.http://www.sciencedirect.com/science/article/pii/S0022227520389641rabbitdietsucroselactoseturnovercholesterol |
| spellingShingle | N. Iritani W.W. Wells Turnover of cholesterol-4-14C and cholic acid-24-14C by rabbits fed a diet containing lactose Journal of Lipid Research rabbit diet sucrose lactose turnover cholesterol |
| title | Turnover of cholesterol-4-14C and cholic acid-24-14C by rabbits fed a diet containing lactose |
| title_full | Turnover of cholesterol-4-14C and cholic acid-24-14C by rabbits fed a diet containing lactose |
| title_fullStr | Turnover of cholesterol-4-14C and cholic acid-24-14C by rabbits fed a diet containing lactose |
| title_full_unstemmed | Turnover of cholesterol-4-14C and cholic acid-24-14C by rabbits fed a diet containing lactose |
| title_short | Turnover of cholesterol-4-14C and cholic acid-24-14C by rabbits fed a diet containing lactose |
| title_sort | turnover of cholesterol 4 14c and cholic acid 24 14c by rabbits fed a diet containing lactose |
| topic | rabbit diet sucrose lactose turnover cholesterol |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520389641 |
| work_keys_str_mv | AT niritani turnoverofcholesterol414candcholicacid2414cbyrabbitsfedadietcontaininglactose AT wwwells turnoverofcholesterol414candcholicacid2414cbyrabbitsfedadietcontaininglactose |