Seroepidemiology of human <it>Toxoplasma gondii </it>infection in China
<p>Abstract</p> <p>Background</p> <p>Toxoplasmosis is an important zoonotic parasitic disease worldwide. In immune competent individuals, <it>Toxoplasma gondii </it>preferentially infects tissues of central nervous systems, which might be an adding factor of...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-01-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/10/4 |
| _version_ | 1818471256165449728 |
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| author | Ankarklev Johan Xu Huiji Liu Xianying Sang Hong Lu Huijun Hao Lili Xiang Mei Jiang Ning Yin Jigang Xiao Yue Lindh Johan Chen Qijun |
| author_facet | Ankarklev Johan Xu Huiji Liu Xianying Sang Hong Lu Huijun Hao Lili Xiang Mei Jiang Ning Yin Jigang Xiao Yue Lindh Johan Chen Qijun |
| author_sort | Ankarklev Johan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Toxoplasmosis is an important zoonotic parasitic disease worldwide. In immune competent individuals, <it>Toxoplasma gondii </it>preferentially infects tissues of central nervous systems, which might be an adding factor of certain psychiatric disorders. Congenital transmission of <it>T. gondii </it>during pregnancy has been regarded as a risk factor for the health of newborn infants. While in immune-compromised individuals, the parasite can cause life-threatening infections. This study aims to investigate the prevalence of <it>T. gondii </it>infection among clinically healthy <b>i</b>ndividuals and patients with psychiatric disorders in China and to identify the potential risk factors related to the vulnerability of infection in the population.</p> <p>Methods</p> <p>Serum samples from 2634 healthy individuals and 547 patients with certain psychiatric disorders in Changchun and Daqing in the northeast, and in Shanghai in the south of China were examined respectively for the levels of anti-<it>T. gondii </it>IgG by indirect ELISA and a direct agglutination assay. Prevalence of <it>T. gondii </it>infection in the Chinese population in respect of gender, age, residence and health status was systematically analyzed.</p> <p>Results</p> <p>The overall anti-<it>T. gondii </it>IgG prevalence in the study population was 12.3%. In the clinically healthy population 12.5% was sero-positive and in the group with psychiatric disorders 11.3% of these patients were positive with anti-<it>T. gondii </it>IgG. A significant difference (P = 0.004) was found between male and female in the healthy population, the seroprevalence was 10.5% in men versus 14.3% in women. Furthermore, the difference of <it>T. gondii </it>infection rate between male and female in the 20-19 year's group was more obvious, with 6.4% in male population and 14.6% in female population.</p> <p>Conclusion</p> <p>A significant higher prevalence of <it>T. gondii </it>infection was observed in female in the clinically healthy population. No correlation was found between <it>T. gondii </it>infection and psychiatric disorders in this study. Results suggest that women are more exposed to <it>T. gondii </it>infection than men in China. The data argue for deeper investigations for the potential risk factors that threat the female populations.</p> |
| first_indexed | 2024-04-14T03:48:49Z |
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| id | doaj.art-6cd9c9832abb4f0b95fbcc705599b011 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-14T03:48:49Z |
| publishDate | 2010-01-01 |
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| series | BMC Infectious Diseases |
| spelling | doaj.art-6cd9c9832abb4f0b95fbcc705599b0112022-12-22T02:14:07ZengBMCBMC Infectious Diseases1471-23342010-01-01101410.1186/1471-2334-10-4Seroepidemiology of human <it>Toxoplasma gondii </it>infection in ChinaAnkarklev JohanXu HuijiLiu XianyingSang HongLu HuijunHao LiliXiang MeiJiang NingYin JigangXiao YueLindh JohanChen Qijun<p>Abstract</p> <p>Background</p> <p>Toxoplasmosis is an important zoonotic parasitic disease worldwide. In immune competent individuals, <it>Toxoplasma gondii </it>preferentially infects tissues of central nervous systems, which might be an adding factor of certain psychiatric disorders. Congenital transmission of <it>T. gondii </it>during pregnancy has been regarded as a risk factor for the health of newborn infants. While in immune-compromised individuals, the parasite can cause life-threatening infections. This study aims to investigate the prevalence of <it>T. gondii </it>infection among clinically healthy <b>i</b>ndividuals and patients with psychiatric disorders in China and to identify the potential risk factors related to the vulnerability of infection in the population.</p> <p>Methods</p> <p>Serum samples from 2634 healthy individuals and 547 patients with certain psychiatric disorders in Changchun and Daqing in the northeast, and in Shanghai in the south of China were examined respectively for the levels of anti-<it>T. gondii </it>IgG by indirect ELISA and a direct agglutination assay. Prevalence of <it>T. gondii </it>infection in the Chinese population in respect of gender, age, residence and health status was systematically analyzed.</p> <p>Results</p> <p>The overall anti-<it>T. gondii </it>IgG prevalence in the study population was 12.3%. In the clinically healthy population 12.5% was sero-positive and in the group with psychiatric disorders 11.3% of these patients were positive with anti-<it>T. gondii </it>IgG. A significant difference (P = 0.004) was found between male and female in the healthy population, the seroprevalence was 10.5% in men versus 14.3% in women. Furthermore, the difference of <it>T. gondii </it>infection rate between male and female in the 20-19 year's group was more obvious, with 6.4% in male population and 14.6% in female population.</p> <p>Conclusion</p> <p>A significant higher prevalence of <it>T. gondii </it>infection was observed in female in the clinically healthy population. No correlation was found between <it>T. gondii </it>infection and psychiatric disorders in this study. Results suggest that women are more exposed to <it>T. gondii </it>infection than men in China. The data argue for deeper investigations for the potential risk factors that threat the female populations.</p>http://www.biomedcentral.com/1471-2334/10/4 |
| spellingShingle | Ankarklev Johan Xu Huiji Liu Xianying Sang Hong Lu Huijun Hao Lili Xiang Mei Jiang Ning Yin Jigang Xiao Yue Lindh Johan Chen Qijun Seroepidemiology of human <it>Toxoplasma gondii </it>infection in China BMC Infectious Diseases |
| title | Seroepidemiology of human <it>Toxoplasma gondii </it>infection in China |
| title_full | Seroepidemiology of human <it>Toxoplasma gondii </it>infection in China |
| title_fullStr | Seroepidemiology of human <it>Toxoplasma gondii </it>infection in China |
| title_full_unstemmed | Seroepidemiology of human <it>Toxoplasma gondii </it>infection in China |
| title_short | Seroepidemiology of human <it>Toxoplasma gondii </it>infection in China |
| title_sort | seroepidemiology of human it toxoplasma gondii it infection in china |
| url | http://www.biomedcentral.com/1471-2334/10/4 |
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