Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

The identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has previously been hampered by inappropriately tailored in vitro assays of drug response. Therefore, using a pulse model that closely mimics the in vivo pharmacokinetics of p...

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Bibliographic Details
Main Authors: Jordan F Hastings, Alvaro Gonzalez Rajal, Sharissa L Latham, Jeremy ZR Han, Rachael A McCloy, Yolande EI O'Donnell, Monica Phimmachanh, Alexander D Murphy, Adnan Nagrial, Dariush Daneshvar, Venessa Chin, D Neil Watkins, Andrew Burgess, David R Croucher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
platinum chemotherapy
lung adenocarcinoma
chemoresistance
signalling dynamics
P70S6K
p53
Online Access:https://elifesciences.org/articles/53367

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