A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease
Background: In the pathogenesis of inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron’s disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2023-05-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-3431-en.pdf |
| _version_ | 1797788321733148672 |
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| author | Ratih Puspita Febrinasari Indah Sagitaisna Putri Bastomy Eka Rezkita Steven Irving Akhmad Azmiardi Rabbinu Rangga Pribadi Marcellus Simadibrata Yulia Sari |
| author_facet | Ratih Puspita Febrinasari Indah Sagitaisna Putri Bastomy Eka Rezkita Steven Irving Akhmad Azmiardi Rabbinu Rangga Pribadi Marcellus Simadibrata Yulia Sari |
| author_sort | Ratih Puspita Febrinasari |
| collection | DOAJ |
| description | Background: In the pathogenesis of inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron’s disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that increased its transcriptional activity. This study, therefore, used a systematic review and meta-analysis to examine the relationship between the RAGE gene polymorphism and the risk of IBD.
Methods: Databases such as PubMed, Scopus, and Cochrane library were searched to identify the relationship between RAGE gene polymorphisms and IBD susceptibility. We identified three Single Nucleotide Polymorphism (SNPs) (RAGE-429T/C, 374T/A, and G82S). The data were analyzed by RevMan 5.4.
Results: Four studies (932 cases/1366 controls) were included. The findings showed no relationship between RAGE –429T/C and –G82S polymorphisms and the risk of IBD in all genetic models significantly. TT genotype of RAGE –374T/A polymorphisms was related to increased CD risk (OR=1.37; 95%CI=1.04-1.81; P=0.02), while TA genotype was determined to be a protective factor (OR=0.75; 95%CI=0.57-0.99; P=0.04). In UC, A allele of RAGE -374T/A was related to increase risk (OR=1.26; 95%CI=1.04-1.53; P=0.02), while T allele was determined to decrease risk (OR=0.79; 95%CI= 0.65-0.96; P=0.02).
Conclusions: Our findings demonstrated that TT genotype and A allele of RAGE -374T/A polymorphisms were related to CD and UC risks, respectively, while the TA genotype and T allele possibly had a protective effect. RAGE –429T/C and RAGE –G82S polymorphisms were not related to increased IBD risk. |
| first_indexed | 2024-03-13T01:34:53Z |
| format | Article |
| id | doaj.art-6cdc3468c1a04af287d784b054ffca27 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-03-13T01:34:53Z |
| publishDate | 2023-05-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-6cdc3468c1a04af287d784b054ffca272023-07-04T05:13:29ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722023-05-01143412424A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel diseaseRatih Puspita Febrinasari0Indah Sagitaisna Putri1Bastomy Eka Rezkita2Steven Irving3Akhmad Azmiardi4Rabbinu Rangga Pribadi5Marcellus Simadibrata6Yulia Sari7 Department of Pharmacology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia School of Health Sciences Mamba'ul 'Ulum, Surakarta, Indonesia Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia Department of Parasitology, Faculty of Medicine, Universitas Sebelas Maret, Indonesia Background: In the pathogenesis of inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron’s disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that increased its transcriptional activity. This study, therefore, used a systematic review and meta-analysis to examine the relationship between the RAGE gene polymorphism and the risk of IBD. Methods: Databases such as PubMed, Scopus, and Cochrane library were searched to identify the relationship between RAGE gene polymorphisms and IBD susceptibility. We identified three Single Nucleotide Polymorphism (SNPs) (RAGE-429T/C, 374T/A, and G82S). The data were analyzed by RevMan 5.4. Results: Four studies (932 cases/1366 controls) were included. The findings showed no relationship between RAGE –429T/C and –G82S polymorphisms and the risk of IBD in all genetic models significantly. TT genotype of RAGE –374T/A polymorphisms was related to increased CD risk (OR=1.37; 95%CI=1.04-1.81; P=0.02), while TA genotype was determined to be a protective factor (OR=0.75; 95%CI=0.57-0.99; P=0.04). In UC, A allele of RAGE -374T/A was related to increase risk (OR=1.26; 95%CI=1.04-1.53; P=0.02), while T allele was determined to decrease risk (OR=0.79; 95%CI= 0.65-0.96; P=0.02). Conclusions: Our findings demonstrated that TT genotype and A allele of RAGE -374T/A polymorphisms were related to CD and UC risks, respectively, while the TA genotype and T allele possibly had a protective effect. RAGE –429T/C and RAGE –G82S polymorphisms were not related to increased IBD risk.http://caspjim.com/article-1-3431-en.pdfinflammatory bowel diseaseadvanced glycation end products receptorgenetic polymorphismsmeta-analysissystematic review |
| spellingShingle | Ratih Puspita Febrinasari Indah Sagitaisna Putri Bastomy Eka Rezkita Steven Irving Akhmad Azmiardi Rabbinu Rangga Pribadi Marcellus Simadibrata Yulia Sari A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease Caspian Journal of Internal Medicine inflammatory bowel disease advanced glycation end products receptor genetic polymorphisms meta-analysis systematic review |
| title | A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease |
| title_full | A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease |
| title_fullStr | A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease |
| title_full_unstemmed | A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease |
| title_short | A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease |
| title_sort | systematic review and meta analysis of the relationship between advanced glycation end products ceceptor rage gene polymorphisms and the risk of inflammatory bowel disease |
| topic | inflammatory bowel disease advanced glycation end products receptor genetic polymorphisms meta-analysis systematic review |
| url | http://caspjim.com/article-1-3431-en.pdf |
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