Recent advances in understanding contextual TGFβ signaling [version 1; referees: 2 approved]
The appearance of the first animal species on earth coincides with the emergence of transforming growth factor β (TGFβ) pathways. The evolution of these animals into more complex organisms coincides with a progressively increased TGFβ repertoire through gene duplications and divergence, making secre...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2017-05-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-749/v1 |
| _version_ | 1819063834183204864 |
|---|---|
| author | Arshad Ayyaz Liliana Attisano Jeffrey L Wrana |
| author_facet | Arshad Ayyaz Liliana Attisano Jeffrey L Wrana |
| author_sort | Arshad Ayyaz |
| collection | DOAJ |
| description | The appearance of the first animal species on earth coincides with the emergence of transforming growth factor β (TGFβ) pathways. The evolution of these animals into more complex organisms coincides with a progressively increased TGFβ repertoire through gene duplications and divergence, making secreted TGFβ molecules the largest family of morphogenetic proteins in humans. It is therefore not surprising that TGFβ pathways govern numerous aspects of human biology from early embryonic development to regeneration, hematopoiesis, neurogenesis, and immunity. Such heavy reliance on these pathways is reflected in the susceptibility to minor perturbations in pathway components that can lead to dysregulated signaling and a diverse range of human pathologies such as cancer, fibrosis, and developmental disorders. Attempts to comprehensively resolve these signaling cascades are complicated by the long-recognized paradoxical role the pathway plays in cell biology. Recently, several groups have probed examples of the disparate aspects of TGFβ biology in a variety of animal models and uncovered novel context-dependent regulatory mechanisms. Here, we briefly review recent advancements and discuss their overall impact in directing future TGFβ research. |
| first_indexed | 2024-12-21T15:20:58Z |
| format | Article |
| id | doaj.art-6cdd154e868b4724ae3846b7b4afa423 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T15:20:58Z |
| publishDate | 2017-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-6cdd154e868b4724ae3846b7b4afa4232022-12-21T18:59:02ZengF1000 Research LtdF1000Research2046-14022017-05-01610.12688/f1000research.11295.112188Recent advances in understanding contextual TGFβ signaling [version 1; referees: 2 approved]Arshad Ayyaz0Liliana Attisano1Jeffrey L Wrana2Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, CanadaDepartment of Biochemistry and Donnelly Centre, University of Toronto, Toronto, ON, CanadaDepartment of Molecular Genetics, University of Toronto, Toronto, ON, CanadaThe appearance of the first animal species on earth coincides with the emergence of transforming growth factor β (TGFβ) pathways. The evolution of these animals into more complex organisms coincides with a progressively increased TGFβ repertoire through gene duplications and divergence, making secreted TGFβ molecules the largest family of morphogenetic proteins in humans. It is therefore not surprising that TGFβ pathways govern numerous aspects of human biology from early embryonic development to regeneration, hematopoiesis, neurogenesis, and immunity. Such heavy reliance on these pathways is reflected in the susceptibility to minor perturbations in pathway components that can lead to dysregulated signaling and a diverse range of human pathologies such as cancer, fibrosis, and developmental disorders. Attempts to comprehensively resolve these signaling cascades are complicated by the long-recognized paradoxical role the pathway plays in cell biology. Recently, several groups have probed examples of the disparate aspects of TGFβ biology in a variety of animal models and uncovered novel context-dependent regulatory mechanisms. Here, we briefly review recent advancements and discuss their overall impact in directing future TGFβ research.https://f1000research.com/articles/6-749/v1Cell Growth & DivisionCell SignalingControl of Gene ExpressionDevelopmental Molecular MechanismsImmunomodulationInnate ImmunityLeukocyte ActivationLeukocyte Signaling & Gene ExpressionMedical GeneticsNuclear Structure & FunctionStem Cells & Regeneration |
| spellingShingle | Arshad Ayyaz Liliana Attisano Jeffrey L Wrana Recent advances in understanding contextual TGFβ signaling [version 1; referees: 2 approved] F1000Research Cell Growth & Division Cell Signaling Control of Gene Expression Developmental Molecular Mechanisms Immunomodulation Innate Immunity Leukocyte Activation Leukocyte Signaling & Gene Expression Medical Genetics Nuclear Structure & Function Stem Cells & Regeneration |
| title | Recent advances in understanding contextual TGFβ signaling [version 1; referees: 2 approved] |
| title_full | Recent advances in understanding contextual TGFβ signaling [version 1; referees: 2 approved] |
| title_fullStr | Recent advances in understanding contextual TGFβ signaling [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent advances in understanding contextual TGFβ signaling [version 1; referees: 2 approved] |
| title_short | Recent advances in understanding contextual TGFβ signaling [version 1; referees: 2 approved] |
| title_sort | recent advances in understanding contextual tgfβ signaling version 1 referees 2 approved |
| topic | Cell Growth & Division Cell Signaling Control of Gene Expression Developmental Molecular Mechanisms Immunomodulation Innate Immunity Leukocyte Activation Leukocyte Signaling & Gene Expression Medical Genetics Nuclear Structure & Function Stem Cells & Regeneration |
| url | https://f1000research.com/articles/6-749/v1 |
| work_keys_str_mv | AT arshadayyaz recentadvancesinunderstandingcontextualtgfbsignalingversion1referees2approved AT lilianaattisano recentadvancesinunderstandingcontextualtgfbsignalingversion1referees2approved AT jeffreylwrana recentadvancesinunderstandingcontextualtgfbsignalingversion1referees2approved |