Adverse Event Burden Score—A Versatile Summary Measure for Cancer Clinical Trials

Adverse Event Burden Score—A Versatile Summary Measure for Cancer Clinical Trials

This article introduces the adverse event (AE) burden score. The AE burden by treatment cycle is a weighted sum of all grades and AEs that the patient experienced in a cycle. The overall AE burden score is the total AE burden the patient experienced across all treatment cycles. AE data from two comp...

Full description

Bibliographic Details
Main Authors:	Jennifer G. Le-Rademacher, Shauna Hillman, Elizabeth Storrick, Michelle R. Mahoney, Peter F. Thall, Aminah Jatoi, Sumithra J. Mandrekar
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	Cancers
Subjects:	adverse event clinical trials adverse event burden score safety profile
Online Access:	https://www.mdpi.com/2072-6694/12/11/3251

Similar Items

A comparison of nurses’ and physicians’ perception of cancer treatment burden based on reported adverse events
by: Shing M. Lee, et al.
Published: (2019-08-01)

SYNTAX score as predictor of adverse events in patients after acute myocardial infarction
by: Davidović Aleksandar, et al.
Published: (2021-01-01)

Behavioral, Psychiatric, and Cognitive Adverse Events in Older Persons Treated with Glucocorticoids
by: Ciro Manzo, et al.
Published: (2018-08-01)

Overlap between adverse events (AEs) and serious adverse events (SAEs): a case study of a phase III cancer clinical trial
by: Elizabeth C. James, et al.
Published: (2020-09-01)

Serious adverse events and fatal adverse events associated with nivolumab treatment in cancer patients
by: Bin Zhao, et al.
Published: (2018-10-01)

Appraisal of Intraoperative Adverse Events to Improve Postoperative Care
by: Larsa Gawria, et al.
Published: (2023-03-01)

Adverse events: an expensive and avoidable hospital problem
by: Diego San Jose-Saras, et al.
Published: (2022-12-01)

IL12/23 Blockade with Ustekinumab as a Treatment for Immune-Related Cutaneous Adverse Events
by: Stephanie L. Gu, et al.
Published: (2023-11-01)

Cognitive adverse events in patients with lung cancer treated with checkpoint inhibitor monotherapy: a propensity score-matched analysisResearch in context
by: Yifei Ma, et al.
Published: (2023-05-01)

Treatment patterns, adverse events, and economic burden in a privately insured population of patients with chronic lymphocytic leukemia in the United States
by: Shaum M. Kabadi, et al.
Published: (2019-07-01)

The safety and serious adverse events of approved ALK inhibitors in malignancies: a meta-analysis
by: Hou H, et al.
Published: (2019-05-01)

SASE, Success and Adverse event Score in Endoscopic Retrograde Cholangiopancreatography: a Novel Grading System
by: Andreas Maieron, et al.
Published: (2023-09-01)

Reducing preventable adverse events in obstetrics by improving interprofessional communication skills – Results of an intervention study
by: Beate Hüner, et al.
Published: (2023-01-01)

Effects of secukinumab and ixekizumab on major adverse cardiovascular events in patients with psoriasis: a meta-analysis of randomized controlled trials
by: Yonghong Zhang, et al.
Published: (2024-03-01)

Adverse Events of DOACs in Children
by: Alessandra Bosch, et al.
Published: (2022-07-01)

Cosmetics utilization and associated adverse events: A community based cross-sectional study
by: Sweta Kumari, et al.
Published: (2023-09-01)

Three aspects of acupuncture-related adverse events: Issues around the reporting of acupuncture-related adverse events
by: Tae-Hun Kim, et al.
Published: (2023-09-01)

Are 5-7 Days of Folic Acid Supplementation Necessary prior to Pemetrexed Observations from a Case Series
by: Benjamin R. Griffin, et al.
Published: (2013-06-01)

Magnitude and Impacts of Adverse Events of Injectable Containing Shorter Regimen in Programmatic Management of Multi-Drug Resistant Tuberculosis in Ethiopia: A Retrospective Cohort Study
by: Achalu DL, et al.
Published: (2023-11-01)

Economic burden related to chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system
by: Rashid N, et al.
Published: (2016-10-01)

Rheumatological Adverse Events Following Immunotherapy for Cancer
by: Ioana Cretu, et al.
Published: (2022-01-01)

Hyperuricaemia, gout and related adverse events associated with antihypertensive drugs: A real-world analysis using the FDA adverse event reporting system
by: Xue-Feng Jiao, et al.
Published: (2023-01-01)

A novel standard to evaluate the impact of therapeutic agents on patient safety – The BURDEN OF THERAPY™©∗
by: Ayad K. Abdulahad, et al.
Published: (2016-12-01)

Signal mining and analysis for adverse events of avatrombopag based on FAERS
by: XIONG Rui, et al.
Published: (2024-02-01)

Adverse drug events caused by medication errors in medical inpatients
by: B Hardmeier, et al.
Published: (2004-11-01)

Vaccine hesitancy: evidence from an adverse events following immunization database, and the role of cognitive biases
by: Hossein Azarpanah, et al.
Published: (2021-09-01)

ODAE: Ontology-based systematic representation and analysis of drug adverse events and its usage in study of adverse events given different patient age and disease conditions
by: Hong Yu, et al.
Published: (2019-05-01)

OAE-based data mining and modeling analysis of adverse events associated with three licensed HPV vaccines
by: Wenrui Zi, et al.
Published: (2022-11-01)

Epidemiology of medical adverse events: perspectives from a single institute in Taiwan
by: Chen-Hsu Wang, et al.
Published: (2016-06-01)

Perception of the Disclosure of Adverse Events in a Latin American Culture: A National Survey
by: Thiago Gomes Romano, et al.
Published: (2022-08-01)

Immune-related adverse events: a retrospective look into the future of oncology in the intensive care unit
by: Adrien Joseph, et al.
Published: (2020-10-01)

Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting
by: John S. Finnell, et al.
Published: (2018-02-01)

Adverse events and in-hospital mortality: an analysis of all deaths in a Norwegian health trust during 2011
by: Hans Flaatten, et al.
Published: (2017-07-01)

Adverse drug reactions in psychiatry outpatient department of a tertiary care hospital in Western Uttar Pradesh: An observational study
by: Jaspreet Kaur Sidhu, et al.
Published: (2022-01-01)

Severe Late-Onset Grade III-IV Adverse Events under Immunotherapy: A Retrospective Study of 79 Cases
by: Jean-Matthieu L’Orphelin, et al.
Published: (2021-09-01)

Patterns of toxicity burden for FDA-approved immune checkpoint inhibitors in the United States
by: Fan Yang, et al.
Published: (2023-01-01)

Adverse Events of Oncologic Immunotherapy and Their Management
by: Fedricker Diane Barber
Published: (2019-01-01)

Comparison of immune checkpoint inhibitors related to pulmonary adverse events: a retrospective analysis of clinical studies and network meta-analysis
by: Baohui Hong, et al.
Published: (2024-02-01)

Predictive values of metabolic score for insulin resistance on risk of major adverse cardiovascular events and comparison with other insulin resistance indices among Chinese with and without diabetes mellitus: Results from the 4C cohort study
by: Limeng Pan, et al.
Published: (2023-08-01)

Adverse reactions by antibiotics and non-steroidal anti-inflammatory drugs
by: Karen Orellana, et al.
Published: (2022-03-01)