Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China
Abstract Background The present study aimed to assess the cumulative incidence of major depressive disorder (MDD) among rural Chinese residents. Furthermore, we intended to estimate whether metabolic syndrome (MetS) was associated with MDD by both cross-sectional and prospective analysis. Method Dat...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-020-02668-z |
| _version_ | 1818498989935296512 |
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| author | Shasha Yu Xiaofan Guo Guang Xiao Li Hongmei Yang Liqiang Zheng Yingxian Sun |
| author_facet | Shasha Yu Xiaofan Guo Guang Xiao Li Hongmei Yang Liqiang Zheng Yingxian Sun |
| author_sort | Shasha Yu |
| collection | DOAJ |
| description | Abstract Background The present study aimed to assess the cumulative incidence of major depressive disorder (MDD) among rural Chinese residents. Furthermore, we intended to estimate whether metabolic syndrome (MetS) was associated with MDD by both cross-sectional and prospective analysis. Method Data of 11,675 residents (46.3% men) was used for cross-sectional analysis. The residents were followed up with median 4.66 years. MDD was diagnosed using the Patient Health Questionnaire-9 (PHQ-9). The data of 2796 individuals without any depressive symptoms was used for prospective analysis. Result With median of 4.66 years follow-up, the cumulative incidence of MDD among rural residents was 3.9%. Women had significantly higher cumulative incidence of MDD than men (5.3% for women and 2.9% for men, P < 0.01). The incidence of MDD was significantly higher among women with MetS (7.3% vs. 3.8%, P < 0.001), hypertriglyceridemia (7.0% vs. 4.5%, P < 0.001) or elevated blood pressure (6.4% vs. 3.4%, P < 0.001) at baseline compared with those without them. There was no incidence difference of MDD among men with or without baseline metabolic disorders. In prospective study, after adjusting possible confounders, baseline MetS was associated with higher incidence of MDD (OR: 1.82, 95%CI: 1.01, 3.27, P = 0.045) in women but not men (OR: 1.84, 95%CI: 0.88, 3.83, P = 0.104). Conclusion Cumulative incidence of MDD in rural China was higher among women than among men. Baseline MetS was associated with higher cumulative incidence of MDD in women but not men. More concern should be put on women with MetS in case of onset depressive symptom in future. |
| first_indexed | 2024-12-10T20:23:02Z |
| format | Article |
| id | doaj.art-6ce34233d23041b5bfb1e67aba567649 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-10T20:23:02Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-6ce34233d23041b5bfb1e67aba5676492022-12-22T01:34:58ZengBMCBMC Psychiatry1471-244X2020-05-0120111010.1186/s12888-020-02668-zMetabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast ChinaShasha Yu0Xiaofan Guo1Guang Xiao Li2Hongmei Yang3Liqiang Zheng4Yingxian Sun5Department of Cardiology, First Hospital of China Medical UniversityDepartment of Cardiology, First Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Institute of Cardiovascular Diseases, First Hospital of China Medical UniversityDepartment of Cardiology, First Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Cardiology, First Hospital of China Medical UniversityAbstract Background The present study aimed to assess the cumulative incidence of major depressive disorder (MDD) among rural Chinese residents. Furthermore, we intended to estimate whether metabolic syndrome (MetS) was associated with MDD by both cross-sectional and prospective analysis. Method Data of 11,675 residents (46.3% men) was used for cross-sectional analysis. The residents were followed up with median 4.66 years. MDD was diagnosed using the Patient Health Questionnaire-9 (PHQ-9). The data of 2796 individuals without any depressive symptoms was used for prospective analysis. Result With median of 4.66 years follow-up, the cumulative incidence of MDD among rural residents was 3.9%. Women had significantly higher cumulative incidence of MDD than men (5.3% for women and 2.9% for men, P < 0.01). The incidence of MDD was significantly higher among women with MetS (7.3% vs. 3.8%, P < 0.001), hypertriglyceridemia (7.0% vs. 4.5%, P < 0.001) or elevated blood pressure (6.4% vs. 3.4%, P < 0.001) at baseline compared with those without them. There was no incidence difference of MDD among men with or without baseline metabolic disorders. In prospective study, after adjusting possible confounders, baseline MetS was associated with higher incidence of MDD (OR: 1.82, 95%CI: 1.01, 3.27, P = 0.045) in women but not men (OR: 1.84, 95%CI: 0.88, 3.83, P = 0.104). Conclusion Cumulative incidence of MDD in rural China was higher among women than among men. Baseline MetS was associated with higher cumulative incidence of MDD in women but not men. More concern should be put on women with MetS in case of onset depressive symptom in future.http://link.springer.com/article/10.1186/s12888-020-02668-zMajor depressive symptomGender differenceIncidenceMetSMetabolic disorders |
| spellingShingle | Shasha Yu Xiaofan Guo Guang Xiao Li Hongmei Yang Liqiang Zheng Yingxian Sun Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China BMC Psychiatry Major depressive symptom Gender difference Incidence MetS Metabolic disorders |
| title | Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China |
| title_full | Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China |
| title_fullStr | Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China |
| title_full_unstemmed | Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China |
| title_short | Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China |
| title_sort | metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural northeast china |
| topic | Major depressive symptom Gender difference Incidence MetS Metabolic disorders |
| url | http://link.springer.com/article/10.1186/s12888-020-02668-z |
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