Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer
Quercetin belongs to the broader category of polyphenols. It is found, in particular, among the flavonols, and along with kaempferol, myricetin and isorhamnetin, it is recognized as a foreign substance after ingestion in contrast to vitamins. Quercetin occurs mainly linked to sugars with the most co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/10/3/37 |
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| author | Aikaterini-Spyridoula Michala Agathi Pritsa |
| author_facet | Aikaterini-Spyridoula Michala Agathi Pritsa |
| author_sort | Aikaterini-Spyridoula Michala |
| collection | DOAJ |
| description | Quercetin belongs to the broader category of polyphenols. It is found, in particular, among the flavonols, and along with kaempferol, myricetin and isorhamnetin, it is recognized as a foreign substance after ingestion in contrast to vitamins. Quercetin occurs mainly linked to sugars with the most common compounds being quercetin-3-O-glucoside or as an aglycone, especially in the plant population. The aim of this review is to present a recent bibliography on the mechanisms of quercetin absorption and metabolism, bioavailability, and antioxidant and the clinical effects in diabetes and cancer. The literature reports a positive effect of quercetin on oxidative stress, cancer, and the regulation of blood sugar levels. Moreover, research-administered drug dosages of up to 2000 mg per day showed mild to no symptoms of overdose. It should be noted that quercetin is no longer considered a carcinogenic substance. The daily intake of quercetin in the diet ranges 10 mg–500 mg, depending on the type of products consumed. This review highlights that quercetin is a valuable dietary antioxidant, although a specific daily recommended intake for this substance has not yet been determined and further studies are required to decide a beneficial concentration threshold. |
| first_indexed | 2024-03-10T00:15:58Z |
| format | Article |
| id | doaj.art-6ce3629d82514db99b7b5211c5667e88 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-10T00:15:58Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-6ce3629d82514db99b7b5211c5667e882023-11-23T15:51:29ZengMDPI AGDiseases2079-97212022-06-011033710.3390/diseases10030037Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and CancerAikaterini-Spyridoula Michala0Agathi Pritsa1Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University (IHU), P.O. Box 141, Sindos, 57400 Thessaloniki, GreeceDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University (IHU), P.O. Box 141, Sindos, 57400 Thessaloniki, GreeceQuercetin belongs to the broader category of polyphenols. It is found, in particular, among the flavonols, and along with kaempferol, myricetin and isorhamnetin, it is recognized as a foreign substance after ingestion in contrast to vitamins. Quercetin occurs mainly linked to sugars with the most common compounds being quercetin-3-O-glucoside or as an aglycone, especially in the plant population. The aim of this review is to present a recent bibliography on the mechanisms of quercetin absorption and metabolism, bioavailability, and antioxidant and the clinical effects in diabetes and cancer. The literature reports a positive effect of quercetin on oxidative stress, cancer, and the regulation of blood sugar levels. Moreover, research-administered drug dosages of up to 2000 mg per day showed mild to no symptoms of overdose. It should be noted that quercetin is no longer considered a carcinogenic substance. The daily intake of quercetin in the diet ranges 10 mg–500 mg, depending on the type of products consumed. This review highlights that quercetin is a valuable dietary antioxidant, although a specific daily recommended intake for this substance has not yet been determined and further studies are required to decide a beneficial concentration threshold.https://www.mdpi.com/2079-9721/10/3/37quercetinflavonolantioxidantdiabetescancer |
| spellingShingle | Aikaterini-Spyridoula Michala Agathi Pritsa Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer Diseases quercetin flavonol antioxidant diabetes cancer |
| title | Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer |
| title_full | Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer |
| title_fullStr | Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer |
| title_full_unstemmed | Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer |
| title_short | Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer |
| title_sort | quercetin a molecule of great biochemical and clinical value and its beneficial effect on diabetes and cancer |
| topic | quercetin flavonol antioxidant diabetes cancer |
| url | https://www.mdpi.com/2079-9721/10/3/37 |
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