An alternative non-invasive treatment for Peyronie's disease
OBJECTIVE: Surgical correction of the deformity and plaque caused by Peyronie's disease has some important disadvantages and extracorporeal shockwave therapy (ESWT) emerged as a new promising therapy. We evaluated prospectively the efficacy and safety of the association of high dose vitamin E a...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2004-06-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382004000300004 |
| _version_ | 1828931011493232640 |
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| author | Joaquim A. Claro Carlo C. Passerotti Antonio C. Figueiredo Neto Archimedes Nardozza Jr. Valdemar Ortiz Miguel Srougi |
| author_facet | Joaquim A. Claro Carlo C. Passerotti Antonio C. Figueiredo Neto Archimedes Nardozza Jr. Valdemar Ortiz Miguel Srougi |
| author_sort | Joaquim A. Claro |
| collection | DOAJ |
| description | OBJECTIVE: Surgical correction of the deformity and plaque caused by Peyronie's disease has some important disadvantages and extracorporeal shockwave therapy (ESWT) emerged as a new promising therapy. We evaluated prospectively the efficacy and safety of the association of high dose vitamin E and ESWT as a non-invasive treatment for the disease. MATERIALS AND METHODS: Twenty-five patients 42 to 68 years old (mean = 54) presenting penile deviation and sexual distress caused by Peyronie's disease were treated in a non-invasive manner. The time of penile deviation ranged from 16 to 52 months (mean = 30). All patients had previous unsuccessful treatment for Peyronie's disease. The angulation's deformity of the penis was assessed by photography at home. The patients received vitamin E (l.200 mg daily) during 3 months and underwent 3 to 6 sessions (mean = 3) of ESWT (3,000 to 4,000 shockwaves) at a power level of l to 2 at 1-week intervals. RESULTS: From 25 patients treated, 16 (64%) reported an improvement in penile angulation, with a mean reduction of 21 degrees (10 to 40). Eight patients reported improvement in their spontaneous erections. Overall, the patients presented only minimal bruising at the site of treatment and skin hematoma. Four patients presented urethral bleeding. The mean angulation after treatment in the control group was 48.67 degrees (30 - 70) and in the study group was 24.42 degrees (0 - 70), statistically significant. CONCLUSION: Considering the common complications and the unsatisfactory outcome of the surgical correction for Peyronie's disease, the association of high dose vitamin E and ESWT represents a good option for a non-invasive, effective and safe treatment of the penile deformity. |
| first_indexed | 2024-12-14T00:41:10Z |
| format | Article |
| id | doaj.art-6ce49cb1c3384153947b2fd2756dd284 |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-12-14T00:41:10Z |
| publishDate | 2004-06-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-6ce49cb1c3384153947b2fd2756dd2842022-12-21T23:24:22ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192004-06-0130319920410.1590/S1677-55382004000300004An alternative non-invasive treatment for Peyronie's diseaseJoaquim A. ClaroCarlo C. PasserottiAntonio C. Figueiredo NetoArchimedes Nardozza Jr.Valdemar OrtizMiguel SrougiOBJECTIVE: Surgical correction of the deformity and plaque caused by Peyronie's disease has some important disadvantages and extracorporeal shockwave therapy (ESWT) emerged as a new promising therapy. We evaluated prospectively the efficacy and safety of the association of high dose vitamin E and ESWT as a non-invasive treatment for the disease. MATERIALS AND METHODS: Twenty-five patients 42 to 68 years old (mean = 54) presenting penile deviation and sexual distress caused by Peyronie's disease were treated in a non-invasive manner. The time of penile deviation ranged from 16 to 52 months (mean = 30). All patients had previous unsuccessful treatment for Peyronie's disease. The angulation's deformity of the penis was assessed by photography at home. The patients received vitamin E (l.200 mg daily) during 3 months and underwent 3 to 6 sessions (mean = 3) of ESWT (3,000 to 4,000 shockwaves) at a power level of l to 2 at 1-week intervals. RESULTS: From 25 patients treated, 16 (64%) reported an improvement in penile angulation, with a mean reduction of 21 degrees (10 to 40). Eight patients reported improvement in their spontaneous erections. Overall, the patients presented only minimal bruising at the site of treatment and skin hematoma. Four patients presented urethral bleeding. The mean angulation after treatment in the control group was 48.67 degrees (30 - 70) and in the study group was 24.42 degrees (0 - 70), statistically significant. CONCLUSION: Considering the common complications and the unsatisfactory outcome of the surgical correction for Peyronie's disease, the association of high dose vitamin E and ESWT represents a good option for a non-invasive, effective and safe treatment of the penile deformity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382004000300004penisPeyronie's diseaseextracorporeal shockwave lithotripsyvitamin Etreatment |
| spellingShingle | Joaquim A. Claro Carlo C. Passerotti Antonio C. Figueiredo Neto Archimedes Nardozza Jr. Valdemar Ortiz Miguel Srougi An alternative non-invasive treatment for Peyronie's disease International Brazilian Journal of Urology penis Peyronie's disease extracorporeal shockwave lithotripsy vitamin E treatment |
| title | An alternative non-invasive treatment for Peyronie's disease |
| title_full | An alternative non-invasive treatment for Peyronie's disease |
| title_fullStr | An alternative non-invasive treatment for Peyronie's disease |
| title_full_unstemmed | An alternative non-invasive treatment for Peyronie's disease |
| title_short | An alternative non-invasive treatment for Peyronie's disease |
| title_sort | alternative non invasive treatment for peyronie s disease |
| topic | penis Peyronie's disease extracorporeal shockwave lithotripsy vitamin E treatment |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382004000300004 |
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