Exosomal lncRNA TUG1 derived from human urine-derived stem cells attenuates renal ischemia/reperfusion injury by interacting with SRSF1 to regulate ASCL4-mediated ferroptosis

Exosomal lncRNA TUG1 derived from human urine-derived stem cells attenuates renal ischemia/reperfusion injury by interacting with SRSF1 to regulate ASCL4-mediated ferroptosis

Abstract Background Human urine-derived stem cells (USCs)-derived exosomes (USC-Exo) could improve kidney ischemia/reperfusion injury (IRI), while the underlying mechanisms of this protective effect remain unclear. Methods Human USCs and USC-Exo were isolated and verified by morphology and specific...

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Bibliographic Details
Main Authors: Zejia Sun, Jiyue Wu, Qing Bi, Wei Wang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
LncRNA TUG1
Urine-derived stem cells
Exosomes
Ferroptosis
Ischemia/reperfusion injury
Acute kidney injury
Online Access:https://doi.org/10.1186/s13287-022-02986-x

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