Accelerating Decreases in the Incidences of Hepatocellular Carcinoma at a Younger Age in Shanghai Are Associated With Hepatitis B Virus Vaccination
BackgroundRoutine vaccination of infants for protecting against hepatitis B virus (HBV) infection and its serious consequences, including hepatocellular cancer (HCC), has been carried out in Shanghai, China, since 1986. We therefore have examined the trend of HBV infection and HCC incidences before...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.855945/full |
| _version_ | 1811272383042945024 |
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| author | Shunzhang Yu Qirong Zhu Ying Zheng Chunxiao Wu Hong Ren Xing Liu Zhenqiu Liu Yanting Li Qichao Pan Ying-Jie Zheng |
| author_facet | Shunzhang Yu Qirong Zhu Ying Zheng Chunxiao Wu Hong Ren Xing Liu Zhenqiu Liu Yanting Li Qichao Pan Ying-Jie Zheng |
| author_sort | Shunzhang Yu |
| collection | DOAJ |
| description | BackgroundRoutine vaccination of infants for protecting against hepatitis B virus (HBV) infection and its serious consequences, including hepatocellular cancer (HCC), has been carried out in Shanghai, China, since 1986. We therefore have examined the trend of HBV infection and HCC incidences before and after HBV vaccination over decades to assess the potential influences of the Shanghai HBV vaccination program.MethodsData on incidences of HBV infection and HCC were collected from the Shanghai Cancer Registry and the Shanghai HBV vaccination follow-up study. Joint-point regression and the Bayesian age-period-cohort statistical analysis methods were used.ResultsThe incidences of HBV infection dramatically declined from 23.09 and 1.13 per 100,000 for males and females in 2000 to 3.24 (-85.97%) and 0.22 (-80.53%) per 100,000 in 2014, respectively. Sero-epidemiological data from the sampling surveys during 20 years of follow-up showed that less than 1% of people undergoing HBV vaccination have a positive serum HBsAg. Consistently, the annual adjusted standardization rates (ASR) of HCC steadily fell from 33.38 and 11.65 per 100,000 for males and females in 1973 to 17.34 (-49.2%) and 5.60 (-51.9%) per 100,000 in 2014, respectively. The annual percentage change in overall HCC incidences is about -2%. HCC incidences in males at younger age groups (age <50 years old), particularly in those with age <34 groups, showed an accelerating decrease over time, whereas HCC incidences significantly declined in the female population across all age groups except for those under 19 years of age. The results supported that the universal HBV vaccination in newborns is easy to implement with high coverages and is effective for preventing both HBV infection and HCC in populations. |
| first_indexed | 2024-04-12T22:39:20Z |
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| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T22:39:20Z |
| publishDate | 2022-04-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-6ce6d12899084c52b8fc86b12ac67b262022-12-22T03:13:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.855945855945Accelerating Decreases in the Incidences of Hepatocellular Carcinoma at a Younger Age in Shanghai Are Associated With Hepatitis B Virus VaccinationShunzhang Yu0Qirong Zhu1Ying Zheng2Chunxiao Wu3Hong Ren4Xing Liu5Zhenqiu Liu6Yanting Li7Qichao Pan8Ying-Jie Zheng9School of Public Health, Fudan University, Shanghai, ChinaChildren’s Hospital, Fudan University, Shanghai, ChinaDepartment of Cancer Prevention, Fudan University Shanghai Cancer Center, Shanghai, ChinaCancer Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaCancer Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaCancer Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaCancer Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaBackgroundRoutine vaccination of infants for protecting against hepatitis B virus (HBV) infection and its serious consequences, including hepatocellular cancer (HCC), has been carried out in Shanghai, China, since 1986. We therefore have examined the trend of HBV infection and HCC incidences before and after HBV vaccination over decades to assess the potential influences of the Shanghai HBV vaccination program.MethodsData on incidences of HBV infection and HCC were collected from the Shanghai Cancer Registry and the Shanghai HBV vaccination follow-up study. Joint-point regression and the Bayesian age-period-cohort statistical analysis methods were used.ResultsThe incidences of HBV infection dramatically declined from 23.09 and 1.13 per 100,000 for males and females in 2000 to 3.24 (-85.97%) and 0.22 (-80.53%) per 100,000 in 2014, respectively. Sero-epidemiological data from the sampling surveys during 20 years of follow-up showed that less than 1% of people undergoing HBV vaccination have a positive serum HBsAg. Consistently, the annual adjusted standardization rates (ASR) of HCC steadily fell from 33.38 and 11.65 per 100,000 for males and females in 1973 to 17.34 (-49.2%) and 5.60 (-51.9%) per 100,000 in 2014, respectively. The annual percentage change in overall HCC incidences is about -2%. HCC incidences in males at younger age groups (age <50 years old), particularly in those with age <34 groups, showed an accelerating decrease over time, whereas HCC incidences significantly declined in the female population across all age groups except for those under 19 years of age. The results supported that the universal HBV vaccination in newborns is easy to implement with high coverages and is effective for preventing both HBV infection and HCC in populations.https://www.frontiersin.org/articles/10.3389/fonc.2022.855945/fullhepatitis B virusmother–infant transmissionhepatitis B vaccinationhepatocellular carcinoma (HCC)prevention |
| spellingShingle | Shunzhang Yu Qirong Zhu Ying Zheng Chunxiao Wu Hong Ren Xing Liu Zhenqiu Liu Yanting Li Qichao Pan Ying-Jie Zheng Accelerating Decreases in the Incidences of Hepatocellular Carcinoma at a Younger Age in Shanghai Are Associated With Hepatitis B Virus Vaccination Frontiers in Oncology hepatitis B virus mother–infant transmission hepatitis B vaccination hepatocellular carcinoma (HCC) prevention |
| title | Accelerating Decreases in the Incidences of Hepatocellular Carcinoma at a Younger Age in Shanghai Are Associated With Hepatitis B Virus Vaccination |
| title_full | Accelerating Decreases in the Incidences of Hepatocellular Carcinoma at a Younger Age in Shanghai Are Associated With Hepatitis B Virus Vaccination |
| title_fullStr | Accelerating Decreases in the Incidences of Hepatocellular Carcinoma at a Younger Age in Shanghai Are Associated With Hepatitis B Virus Vaccination |
| title_full_unstemmed | Accelerating Decreases in the Incidences of Hepatocellular Carcinoma at a Younger Age in Shanghai Are Associated With Hepatitis B Virus Vaccination |
| title_short | Accelerating Decreases in the Incidences of Hepatocellular Carcinoma at a Younger Age in Shanghai Are Associated With Hepatitis B Virus Vaccination |
| title_sort | accelerating decreases in the incidences of hepatocellular carcinoma at a younger age in shanghai are associated with hepatitis b virus vaccination |
| topic | hepatitis B virus mother–infant transmission hepatitis B vaccination hepatocellular carcinoma (HCC) prevention |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.855945/full |
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