Gap-prepulse inhibition of the startle reflex (GPIAS) for tinnitus assessment: current status and future directions
The progress in the field of tinnitus largely depends on the development of a reliable tinnitus animal model. Recently a new method based on the acoustic startle reflex modification was introduced for tinnitus screening in laboratory animals. This method was enthusiastically adopted and now widely...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00088/full |
| _version_ | 1828772359274758144 |
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| author | Alexander eGalazyuk Sylvie eHébert |
| author_facet | Alexander eGalazyuk Sylvie eHébert |
| author_sort | Alexander eGalazyuk |
| collection | DOAJ |
| description | The progress in the field of tinnitus largely depends on the development of a reliable tinnitus animal model. Recently a new method based on the acoustic startle reflex modification was introduced for tinnitus screening in laboratory animals. This method was enthusiastically adopted and now widely used by many scientists in the field due to its seeming simplicity and a number of advantages over the other methods of tinnitus assessment. Furthermore, this method opened an opportunity for tinnitus assessment in humans as well. Unfortunately multiple modifications of data collection and interpretation implemented in different labs make comparisons across studies very difficult. In addition, recent animal and human studies have challenged the original filling-in interpretation of the paradigm. Here we review the current literature to emphasize on the commonalities and differences in data collection and interpretation across laboratories that are using this method for tinnitus assessment. We also propose future research directions that could be taken in order to establish whether or not this method is warranted as an indicator of the presence of tinnitus. |
| first_indexed | 2024-12-11T14:42:14Z |
| format | Article |
| id | doaj.art-6ce84f334b1c4e7fb39bcf7e045099ad |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T14:42:14Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6ce84f334b1c4e7fb39bcf7e045099ad2022-12-22T01:01:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952015-04-01610.3389/fneur.2015.00088135149Gap-prepulse inhibition of the startle reflex (GPIAS) for tinnitus assessment: current status and future directionsAlexander eGalazyuk0Sylvie eHébert1Northest Ohio Medical UniversityUniversité de Montréal, and International laboratory for research on Brain, Music, and Sound (BRAMS)The progress in the field of tinnitus largely depends on the development of a reliable tinnitus animal model. Recently a new method based on the acoustic startle reflex modification was introduced for tinnitus screening in laboratory animals. This method was enthusiastically adopted and now widely used by many scientists in the field due to its seeming simplicity and a number of advantages over the other methods of tinnitus assessment. Furthermore, this method opened an opportunity for tinnitus assessment in humans as well. Unfortunately multiple modifications of data collection and interpretation implemented in different labs make comparisons across studies very difficult. In addition, recent animal and human studies have challenged the original filling-in interpretation of the paradigm. Here we review the current literature to emphasize on the commonalities and differences in data collection and interpretation across laboratories that are using this method for tinnitus assessment. We also propose future research directions that could be taken in order to establish whether or not this method is warranted as an indicator of the presence of tinnitus.http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00088/fullacoustic startle reflexTinnitus assessmentgap-prepulse inhibition of the startle reflexanimal model of tinnitushuman tinnitus |
| spellingShingle | Alexander eGalazyuk Sylvie eHébert Gap-prepulse inhibition of the startle reflex (GPIAS) for tinnitus assessment: current status and future directions Frontiers in Neurology acoustic startle reflex Tinnitus assessment gap-prepulse inhibition of the startle reflex animal model of tinnitus human tinnitus |
| title | Gap-prepulse inhibition of the startle reflex (GPIAS) for tinnitus assessment: current status and future directions |
| title_full | Gap-prepulse inhibition of the startle reflex (GPIAS) for tinnitus assessment: current status and future directions |
| title_fullStr | Gap-prepulse inhibition of the startle reflex (GPIAS) for tinnitus assessment: current status and future directions |
| title_full_unstemmed | Gap-prepulse inhibition of the startle reflex (GPIAS) for tinnitus assessment: current status and future directions |
| title_short | Gap-prepulse inhibition of the startle reflex (GPIAS) for tinnitus assessment: current status and future directions |
| title_sort | gap prepulse inhibition of the startle reflex gpias for tinnitus assessment current status and future directions |
| topic | acoustic startle reflex Tinnitus assessment gap-prepulse inhibition of the startle reflex animal model of tinnitus human tinnitus |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00088/full |
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