Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory

A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element-binding protein 3 (Cpeb3) gene is thought to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. We tested the activity of the murine sequence and found tha...

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Bibliographic Details
Main Authors: Claire C Chen, Joseph Han, Carlene A Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan, Marie Myszka, Liqi Tong, Luiz FM Passalacqua, Timothy Bredy, Marcelo A Wood, Andrej Luptak
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
CPEB3
ribozyme
neuroplasticity
Online Access:https://elifesciences.org/articles/90116

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