Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients
We aimed to study the association of fibroblast growth factor-23 (FGF-23) as a novel cardiovascular risk factor with Doppler pulse wave velocity (PWV) as an arterial stiffness measuring tool in hemodialysis (HD) patients. We conducted a cross-sectional study in which blood samples from 86 HD patient...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=1;spage=95;epage=100;aulast=Ibrahim |
| _version_ | 1818435044855775232 |
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| author | Walaa H Ibrahim Ahmad B Ahmad Noha G Sayed |
| author_facet | Walaa H Ibrahim Ahmad B Ahmad Noha G Sayed |
| author_sort | Walaa H Ibrahim |
| collection | DOAJ |
| description | We aimed to study the association of fibroblast growth factor-23 (FGF-23) as a novel cardiovascular risk factor with Doppler pulse wave velocity (PWV) as an arterial stiffness measuring tool in hemodialysis (HD) patients. We conducted a cross-sectional study in which blood samples from 86 HD patients were obtained to estimate FGF 23 and other parameters. Flow waveforms were obtained at two locations within right common carotid artery, and right femoral artery by Doppler ultrasound with ECG recorded in addition. The time differences between the R wave of the ECG signal and the onset of the flow waveforms at the two sites yield ΔT. Distances between sampling sites were measured using a tape measure. PWV was defined as (m/s) = D (m)/ ΔT (s). In the current study, we found significant positive correlations between Doppler PWV and both age (r = 0.401, P = 0.039) and systolic blood pressure (r = 0.602, P = 0.034), while no significant association between Doppler PWV and FGF-23 (r = 0.123, P = 0.259) could be detected. Serum FGF-23 levels are not significantly associated with Doppler PWV in HD patients. |
| first_indexed | 2024-12-14T16:46:38Z |
| format | Article |
| id | doaj.art-6ce887d7038e443fb59460b4175d47cf |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-14T16:46:38Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-6ce887d7038e443fb59460b4175d47cf2022-12-21T22:54:10ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422018-01-012919510010.4103/1319-2442.225194Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patientsWalaa H IbrahimAhmad B AhmadNoha G SayedWe aimed to study the association of fibroblast growth factor-23 (FGF-23) as a novel cardiovascular risk factor with Doppler pulse wave velocity (PWV) as an arterial stiffness measuring tool in hemodialysis (HD) patients. We conducted a cross-sectional study in which blood samples from 86 HD patients were obtained to estimate FGF 23 and other parameters. Flow waveforms were obtained at two locations within right common carotid artery, and right femoral artery by Doppler ultrasound with ECG recorded in addition. The time differences between the R wave of the ECG signal and the onset of the flow waveforms at the two sites yield ΔT. Distances between sampling sites were measured using a tape measure. PWV was defined as (m/s) = D (m)/ ΔT (s). In the current study, we found significant positive correlations between Doppler PWV and both age (r = 0.401, P = 0.039) and systolic blood pressure (r = 0.602, P = 0.034), while no significant association between Doppler PWV and FGF-23 (r = 0.123, P = 0.259) could be detected. Serum FGF-23 levels are not significantly associated with Doppler PWV in HD patients.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=1;spage=95;epage=100;aulast=Ibrahim |
| spellingShingle | Walaa H Ibrahim Ahmad B Ahmad Noha G Sayed Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients Saudi Journal of Kidney Diseases and Transplantation |
| title | Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients |
| title_full | Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients |
| title_fullStr | Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients |
| title_full_unstemmed | Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients |
| title_short | Association of serum fibroblast growth factor-23 with Doppler pulse wave velocity in hemodialysis patients |
| title_sort | association of serum fibroblast growth factor 23 with doppler pulse wave velocity in hemodialysis patients |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=1;spage=95;epage=100;aulast=Ibrahim |
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