Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer Survivors
Intake of flavonoids is associated with the incidence of breast cancer, but the association between the intake of flavonoids and cancer recurrence is unclear. This study aimed to investigate the hypothesis that intake of flavonoids and flavonoid-rich foods is negatively associated with cancer recurr...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/9/3049 |
| _version_ | 1797517801082060800 |
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| author | Minjung Cheon Minsung Chung Yongsoon Park |
| author_facet | Minjung Cheon Minsung Chung Yongsoon Park |
| author_sort | Minjung Cheon |
| collection | DOAJ |
| description | Intake of flavonoids is associated with the incidence of breast cancer, but the association between the intake of flavonoids and cancer recurrence is unclear. This study aimed to investigate the hypothesis that intake of flavonoids and flavonoid-rich foods is negatively associated with cancer recurrence. Among 572 women who underwent breast cancer surgery, 66 patients had a cancer recurrence. Dietary data were collected using a structured 24-h dietary recall, and intake of flavonoids was calculated based on the Korea Rural Development Administration flavonoid database. Among overweight and obese patients, disease-free survival was associated with intake of flavonoids (<i>p</i> = 0.004) and flavonoid-rich foods (<i>p</i> = 0.003). Intake of flavonoids (hazard ratio (HR) = 0.249, 95% confidence interval (CI): 0.09–0.64) and flavonoid-rich foods (HR = 0.244, 95% CI: 0.09–0.66) was negatively associated with cancer recurrence after adjusting for confounding factors in overweight and obese patients. Consumption of flavonoids and flavonoid-rich foods was lower in overweight and obese patients with cancer recurrence than those without recurrence and in normal-weight patients. This study suggests that intake of flavonoids and flavonoid-rich foods could have beneficial effects on cancer recurrence in overweight and obese breast cancer survivors. |
| first_indexed | 2024-03-10T07:21:17Z |
| format | Article |
| id | doaj.art-6cead22acb7b43a3b9b65ce96885e7f7 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T07:21:17Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6cead22acb7b43a3b9b65ce96885e7f72023-11-22T14:36:33ZengMDPI AGNutrients2072-66432021-08-01139304910.3390/nu13093049Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer SurvivorsMinjung Cheon0Minsung Chung1Yongsoon Park2Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaDepartment of Surgery, Hanyang University Hospital, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaDepartment of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaIntake of flavonoids is associated with the incidence of breast cancer, but the association between the intake of flavonoids and cancer recurrence is unclear. This study aimed to investigate the hypothesis that intake of flavonoids and flavonoid-rich foods is negatively associated with cancer recurrence. Among 572 women who underwent breast cancer surgery, 66 patients had a cancer recurrence. Dietary data were collected using a structured 24-h dietary recall, and intake of flavonoids was calculated based on the Korea Rural Development Administration flavonoid database. Among overweight and obese patients, disease-free survival was associated with intake of flavonoids (<i>p</i> = 0.004) and flavonoid-rich foods (<i>p</i> = 0.003). Intake of flavonoids (hazard ratio (HR) = 0.249, 95% confidence interval (CI): 0.09–0.64) and flavonoid-rich foods (HR = 0.244, 95% CI: 0.09–0.66) was negatively associated with cancer recurrence after adjusting for confounding factors in overweight and obese patients. Consumption of flavonoids and flavonoid-rich foods was lower in overweight and obese patients with cancer recurrence than those without recurrence and in normal-weight patients. This study suggests that intake of flavonoids and flavonoid-rich foods could have beneficial effects on cancer recurrence in overweight and obese breast cancer survivors.https://www.mdpi.com/2072-6643/13/9/3049breast cancerflavonoidsflavonoid-rich foodsobesityrecurrencesurvival |
| spellingShingle | Minjung Cheon Minsung Chung Yongsoon Park Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer Survivors Nutrients breast cancer flavonoids flavonoid-rich foods obesity recurrence survival |
| title | Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer Survivors |
| title_full | Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer Survivors |
| title_fullStr | Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer Survivors |
| title_full_unstemmed | Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer Survivors |
| title_short | Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer Survivors |
| title_sort | association between dietary intake of flavonoids and cancer recurrence among breast cancer survivors |
| topic | breast cancer flavonoids flavonoid-rich foods obesity recurrence survival |
| url | https://www.mdpi.com/2072-6643/13/9/3049 |
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