Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis
Abstract Objective Acute mesenteric vein thrombosis (AMVT) is an acute abdominal disease with onset, rapid progression, and extensive intestinal necrosis that requires immediate surgical resection. The purpose of this study was to determine the risk factors for nosocomial intestinal resection in pat...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-024-03172-4 |
| _version_ | 1797274446098071552 |
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| author | Yu Xu Shang-Tai Dai Hong-Qiao Lu Wei Chen Zhi-Wei Xiong Jiang Liu Yong-Jiang Tang Shi-Kui Guo Kun-Mei Gong |
| author_facet | Yu Xu Shang-Tai Dai Hong-Qiao Lu Wei Chen Zhi-Wei Xiong Jiang Liu Yong-Jiang Tang Shi-Kui Guo Kun-Mei Gong |
| author_sort | Yu Xu |
| collection | DOAJ |
| description | Abstract Objective Acute mesenteric vein thrombosis (AMVT) is an acute abdominal disease with onset, rapid progression, and extensive intestinal necrosis that requires immediate surgical resection. The purpose of this study was to determine the risk factors for nosocomial intestinal resection in patients with AMVT. Methods We retrospectively analysed 64 patients with AMVT diagnosed by CTA at the Affiliated Hospital of Kunming University of Science and Technology from January 2013 to December 2021. We compared patients who underwent intestinal resection (42 patients) with those who did not undergo intestinal resection (22 patients). The area under the ROC curve was evaluated, and a forest map was drawn. Results Among the 64 patients, 6 (9.38%) had a fever, 60 (93.75%) had abdominal pain, 9 (14.06%) had a history of diabetes, 8 (12.5%) had a history of deep vein thrombosis (DVT), and 25 (39.06%) had ascites suggested by B ultrasound or CT after admission. The mean age of all patients was 49.86 ± 16.25 years. The mean age of the patients in the enterectomy group was 47.71 ± 16.20 years. The mean age of the patients in the conservative treatment group (without enterectomy) was 53.95 ± 15.90 years. In the univariate analysis, there were statistically significant differences in leukocyte count (P = 0.003), neutrophil count (P = 0.001), AST (P = 0.048), total bilirubin (P = 0.047), fibrinogen (P = 0.022) and DD2 (P = 0.024) between the two groups. The multivariate logistic regression analysis showed that admission white blood cell count (OR = 1.153, 95% CI: 1.039–1.280, P = 0.007) was an independent risk factor for intestinal resection in patients with AMVT. The ROC curve showed that the white blood cell count (AUC = 0.759 95% CI: 0.620–0.897; P = 0.001; optimal threshold: 7.815; sensitivity: 0.881; specificity: 0.636) had good predictive value for emergency enterectomy for AMVT. Conclusions Among patients with AMVT, patients with a higher white blood cell count at admission were more likely to have intestinal necrosis and require emergency enterectomy. This study is helpful for clinicians to accurately determine whether emergency intestinal resection is needed in patients with AMVT after admission, prevent further intestinal necrosis, and improve the prognosis of patients. |
| first_indexed | 2024-03-07T14:58:29Z |
| format | Article |
| id | doaj.art-6cec08071dad40ecb888fcca0d8fea34 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-07T14:58:29Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-6cec08071dad40ecb888fcca0d8fea342024-03-05T19:17:55ZengBMCBMC Gastroenterology1471-230X2024-02-012411610.1186/s12876-024-03172-4Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosisYu Xu0Shang-Tai Dai1Hong-Qiao Lu2Wei Chen3Zhi-Wei Xiong4Jiang Liu5Yong-Jiang Tang6Shi-Kui Guo7Kun-Mei Gong8Panzhihua Central HospitalThe Affiliated Hospital of Kunming University of Science and TechnologyThe Affiliated Hospital of Kunming University of Science and TechnologyPanzhihua Central HospitalPanzhihua Central HospitalPanzhihua Central HospitalPanzhihua Central HospitalThe Affiliated Hospital of Kunming University of Science and TechnologyThe Affiliated Hospital of Kunming University of Science and TechnologyAbstract Objective Acute mesenteric vein thrombosis (AMVT) is an acute abdominal disease with onset, rapid progression, and extensive intestinal necrosis that requires immediate surgical resection. The purpose of this study was to determine the risk factors for nosocomial intestinal resection in patients with AMVT. Methods We retrospectively analysed 64 patients with AMVT diagnosed by CTA at the Affiliated Hospital of Kunming University of Science and Technology from January 2013 to December 2021. We compared patients who underwent intestinal resection (42 patients) with those who did not undergo intestinal resection (22 patients). The area under the ROC curve was evaluated, and a forest map was drawn. Results Among the 64 patients, 6 (9.38%) had a fever, 60 (93.75%) had abdominal pain, 9 (14.06%) had a history of diabetes, 8 (12.5%) had a history of deep vein thrombosis (DVT), and 25 (39.06%) had ascites suggested by B ultrasound or CT after admission. The mean age of all patients was 49.86 ± 16.25 years. The mean age of the patients in the enterectomy group was 47.71 ± 16.20 years. The mean age of the patients in the conservative treatment group (without enterectomy) was 53.95 ± 15.90 years. In the univariate analysis, there were statistically significant differences in leukocyte count (P = 0.003), neutrophil count (P = 0.001), AST (P = 0.048), total bilirubin (P = 0.047), fibrinogen (P = 0.022) and DD2 (P = 0.024) between the two groups. The multivariate logistic regression analysis showed that admission white blood cell count (OR = 1.153, 95% CI: 1.039–1.280, P = 0.007) was an independent risk factor for intestinal resection in patients with AMVT. The ROC curve showed that the white blood cell count (AUC = 0.759 95% CI: 0.620–0.897; P = 0.001; optimal threshold: 7.815; sensitivity: 0.881; specificity: 0.636) had good predictive value for emergency enterectomy for AMVT. Conclusions Among patients with AMVT, patients with a higher white blood cell count at admission were more likely to have intestinal necrosis and require emergency enterectomy. This study is helpful for clinicians to accurately determine whether emergency intestinal resection is needed in patients with AMVT after admission, prevent further intestinal necrosis, and improve the prognosis of patients.https://doi.org/10.1186/s12876-024-03172-4White blood cell countAcute mesenteric vein thrombosisEnterectomy |
| spellingShingle | Yu Xu Shang-Tai Dai Hong-Qiao Lu Wei Chen Zhi-Wei Xiong Jiang Liu Yong-Jiang Tang Shi-Kui Guo Kun-Mei Gong Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis BMC Gastroenterology White blood cell count Acute mesenteric vein thrombosis Enterectomy |
| title | Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis |
| title_full | Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis |
| title_fullStr | Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis |
| title_full_unstemmed | Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis |
| title_short | Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis |
| title_sort | correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis |
| topic | White blood cell count Acute mesenteric vein thrombosis Enterectomy |
| url | https://doi.org/10.1186/s12876-024-03172-4 |
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