Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana.Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of canna...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-09-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02009/full |
| _version_ | 1828528470917906432 |
|---|---|
| author | José A. Crippa José A. Crippa Francisco S. Guimarães Francisco S. Guimarães Alline C. Campos Alline C. Campos Antonio W. Zuardi Antonio W. Zuardi |
| author_facet | José A. Crippa José A. Crippa Francisco S. Guimarães Francisco S. Guimarães Alline C. Campos Alline C. Campos Antonio W. Zuardi Antonio W. Zuardi |
| author_sort | José A. Crippa |
| collection | DOAJ |
| description | Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana.Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry.Methods: A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers.Results: CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties. In addition, basic and clinical investigations on the effects of CBD have been carried out in the context of many other health conditions, including its potential use in epilepsy, substance abuse and dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders, and Parkinson.Discussion: CBD is an useful and promising molecule that may help patients with a number of clinical conditions. Controlled clinical trials with different neuropsychiatric populations that are currently under investigation should bring important answers in the near future and support the translation of research findings to clinical settings. |
| first_indexed | 2024-12-11T21:53:05Z |
| format | Article |
| id | doaj.art-6cedb9184d234aba8b19dd6d6aaaf383 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T21:53:05Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6cedb9184d234aba8b19dd6d6aaaf3832022-12-22T00:49:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02009318736Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New AgeJosé A. Crippa0José A. Crippa1Francisco S. Guimarães2Francisco S. Guimarães3Alline C. Campos4Alline C. Campos5Antonio W. Zuardi6Antonio W. Zuardi7Department of Neurosciences and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, BrazilNational Institute for Translational Medicine (INCT-TM; CNPq), São Paulo, BrazilNational Institute for Translational Medicine (INCT-TM; CNPq), São Paulo, BrazilDepartment of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, BrazilNational Institute for Translational Medicine (INCT-TM; CNPq), São Paulo, BrazilDepartment of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, BrazilDepartment of Neurosciences and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, BrazilNational Institute for Translational Medicine (INCT-TM; CNPq), São Paulo, BrazilBackground: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana.Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry.Methods: A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers.Results: CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties. In addition, basic and clinical investigations on the effects of CBD have been carried out in the context of many other health conditions, including its potential use in epilepsy, substance abuse and dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders, and Parkinson.Discussion: CBD is an useful and promising molecule that may help patients with a number of clinical conditions. Controlled clinical trials with different neuropsychiatric populations that are currently under investigation should bring important answers in the near future and support the translation of research findings to clinical settings.https://www.frontiersin.org/article/10.3389/fimmu.2018.02009/fullcannabidiolCBDCannabis sativaanxiolyticantiepilepticneuroprotection |
| spellingShingle | José A. Crippa José A. Crippa Francisco S. Guimarães Francisco S. Guimarães Alline C. Campos Alline C. Campos Antonio W. Zuardi Antonio W. Zuardi Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age Frontiers in Immunology cannabidiol CBD Cannabis sativa anxiolytic antiepileptic neuroprotection |
| title | Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age |
| title_full | Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age |
| title_fullStr | Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age |
| title_full_unstemmed | Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age |
| title_short | Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age |
| title_sort | translational investigation of the therapeutic potential of cannabidiol cbd toward a new age |
| topic | cannabidiol CBD Cannabis sativa anxiolytic antiepileptic neuroprotection |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02009/full |
| work_keys_str_mv | AT joseacrippa translationalinvestigationofthetherapeuticpotentialofcannabidiolcbdtowardanewage AT joseacrippa translationalinvestigationofthetherapeuticpotentialofcannabidiolcbdtowardanewage AT franciscosguimaraes translationalinvestigationofthetherapeuticpotentialofcannabidiolcbdtowardanewage AT franciscosguimaraes translationalinvestigationofthetherapeuticpotentialofcannabidiolcbdtowardanewage AT allineccampos translationalinvestigationofthetherapeuticpotentialofcannabidiolcbdtowardanewage AT allineccampos translationalinvestigationofthetherapeuticpotentialofcannabidiolcbdtowardanewage AT antoniowzuardi translationalinvestigationofthetherapeuticpotentialofcannabidiolcbdtowardanewage AT antoniowzuardi translationalinvestigationofthetherapeuticpotentialofcannabidiolcbdtowardanewage |