The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C
Aim: to find out the predictive value of blood serum biochemical parameters PAPP-A (pregnancy-associated plasma protein A) and β-hCG (beta subunit of human chorionic gonadotropin) in the assessment of unfavorable pregnancy outcomes in women infected by human immunodeficiency virus (HIV) as well as v...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2022-01-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1182 |
| _version_ | 1797884065842462720 |
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| author | S. Yu. Pseush L. V. Zozulya L. L. Mikhaleva |
| author_facet | S. Yu. Pseush L. V. Zozulya L. L. Mikhaleva |
| author_sort | S. Yu. Pseush |
| collection | DOAJ |
| description | Aim: to find out the predictive value of blood serum biochemical parameters PAPP-A (pregnancy-associated plasma protein A) and β-hCG (beta subunit of human chorionic gonadotropin) in the assessment of unfavorable pregnancy outcomes in women infected by human immunodeficiency virus (HIV) as well as viral hepatitis B (HBV) and C (HCV).Materials and Methods. A retrospective study of the medical records from 52 women was carried out, including 19 HIV-infected women, 9 women with monoinfection HBV or HCV, 11 pregnant women who were co-infected (HIV/HBV or HIV/HCV) and 13 uninfected women. PAPP-A and β-hCG levels, expressed as MoM (multiple of median), were evaluated in all women.Results. Our study revealed that only PAPP-A was prognostically significant for developing chronic placental insufficiency in women with HIV infection and co-infection of HIV together hepatitis B and C. None of the parameters examined were significant in women with HBV or HCV monoinfection. PAPP-A and β-hCG in pregnant women without infections were effective in predicting development of chronic placental insufficiency.Conclusion. PAPP-A can be used as a diagnostic parameter of developing chronic placental insufficiency in pregnant women with monoinfection HIV and co-infection with HIV/HBV or HIV/HCV. |
| first_indexed | 2024-04-10T04:01:41Z |
| format | Article |
| id | doaj.art-6cef5e2d0dac4cd781dd14e0911f02c4 |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:01:41Z |
| publishDate | 2022-01-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-6cef5e2d0dac4cd781dd14e0911f02c42023-03-13T07:09:51ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942022-01-0115668669410.17749/2313-7347/ob.gyn.rep.2021.240692The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and CS. Yu. Pseush0L. V. Zozulya1L. L. Mikhaleva2Kuban State UniversityKuban State UniversityPerinatal Center «Children's Regional Clinical Hospital», Ministry of Health of Krasnodar RegionAim: to find out the predictive value of blood serum biochemical parameters PAPP-A (pregnancy-associated plasma protein A) and β-hCG (beta subunit of human chorionic gonadotropin) in the assessment of unfavorable pregnancy outcomes in women infected by human immunodeficiency virus (HIV) as well as viral hepatitis B (HBV) and C (HCV).Materials and Methods. A retrospective study of the medical records from 52 women was carried out, including 19 HIV-infected women, 9 women with monoinfection HBV or HCV, 11 pregnant women who were co-infected (HIV/HBV or HIV/HCV) and 13 uninfected women. PAPP-A and β-hCG levels, expressed as MoM (multiple of median), were evaluated in all women.Results. Our study revealed that only PAPP-A was prognostically significant for developing chronic placental insufficiency in women with HIV infection and co-infection of HIV together hepatitis B and C. None of the parameters examined were significant in women with HBV or HCV monoinfection. PAPP-A and β-hCG in pregnant women without infections were effective in predicting development of chronic placental insufficiency.Conclusion. PAPP-A can be used as a diagnostic parameter of developing chronic placental insufficiency in pregnant women with monoinfection HIV and co-infection with HIV/HBV or HIV/HCV.https://www.gynecology.su/jour/article/view/1182pregnancyhiv-infectionco-infectionbiochemical screeningpregnancy-associated plasma protein apapp-abeta subunit of human chorionic gonadotropinβ-hcgchronic placental insufficiencyfetal growth retardation syndrome |
| spellingShingle | S. Yu. Pseush L. V. Zozulya L. L. Mikhaleva The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C Акушерство, гинекология и репродукция pregnancy hiv-infection co-infection biochemical screening pregnancy-associated plasma protein a papp-a beta subunit of human chorionic gonadotropin β-hcg chronic placental insufficiency fetal growth retardation syndrome |
| title | The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C |
| title_full | The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C |
| title_fullStr | The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C |
| title_full_unstemmed | The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C |
| title_short | The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C |
| title_sort | predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with hiv as well as hepatitis b and c |
| topic | pregnancy hiv-infection co-infection biochemical screening pregnancy-associated plasma protein a papp-a beta subunit of human chorionic gonadotropin β-hcg chronic placental insufficiency fetal growth retardation syndrome |
| url | https://www.gynecology.su/jour/article/view/1182 |
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