Discovery of Multitarget-Directed Ligands Against Influenza A Virus From Compound Yizhihao Through a Predictive System for Compound-Protein Interactions

Discovery of Multitarget-Directed Ligands Against Influenza A Virus From Compound Yizhihao Through a Predictive System for Compound-Protein Interactions

Influenza A virus (IAV) is a threat to public health due to its high mutation rate and resistance to existing drugs. In this investigation, 15 targets selected from an influenza virus–host interaction network were successfully constructed as a multitarget virtual screening system for new drug discov...

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Bibliographic Details
Main Authors: Lvjie Xu, Wen Jiang, Hao Jia, Lishu Zheng, Jianguo Xing, Ailin Liu, Guanhua Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
influenza A virus
compound yizhihao
multitarget
virtual screening
in vitro evaluation
biological process analysis
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00016/full

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