Clinical Features and Outcomes of Patients with Idiopathic Inflammatory Myositis-Associated Interstitial Lung Disease in Rural Appalachia: A Cross-Sectional Study
Background: Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune disorders often complicated by interstitial lung disease (ILD). The clinical characteristics and outcomes of IIM-associated ILD have been reported variably, but the literature on rural populations is scarce. Methods: A r...
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1294 |
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| author | Vishal Deepak Bhanusowmya Buragamadagu Fnu Rida Ul Jannat Rachel Salyer Ty Landis Sayanika Kaur Bathmapriya Balakrishnan |
| author_facet | Vishal Deepak Bhanusowmya Buragamadagu Fnu Rida Ul Jannat Rachel Salyer Ty Landis Sayanika Kaur Bathmapriya Balakrishnan |
| author_sort | Vishal Deepak |
| collection | DOAJ |
| description | Background: Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune disorders often complicated by interstitial lung disease (ILD). The clinical characteristics and outcomes of IIM-associated ILD have been reported variably, but the literature on rural populations is scarce. Methods: A retrospective cross-sectional study was conducted at a rural tertiary academic medical center. Twenty-nine patients met the final inclusion criteria. The primary outcome was to assess the disease state and immunological and radiographic features of IIM-associated ILD. Secondary outcomes included disease progression, ILD exacerbation, mortality rate, and factors associated with poor outcome. Results: Dermatomyositis (n = 15, 51.72%) followed by polymyositis (n = 8, 27.58%) were predominant myopathies. The most common autoantibodies were anti-Jo1 antibodies (n = 11, 37.93%). Indeterminate usual interstitial pneumonitis (41.30%, n = 12) was the most common radiographic pattern followed by non-specific interstitial pneumonia (n = 5, 17.24%). ILD exacerbation (n = 14, 66.66%) and mortality rate (n = 6, 20.69%) were high. Albumin levels were significantly lower in patients who died. Conclusions: The clinical characteristics of patients with IIM-associated ILD in rural Appalachia exhibit notable distinctions, and outcomes are worse compared to other populations. Larger studies are needed to investigate other prognostics factors and longitudinal trends of clinical characteristics and outcomes of IIM-associated ILD in rural populations. |
| first_indexed | 2024-04-25T00:26:38Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:38Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6cf21f8f22fd4820a613290d9dfa15562024-03-12T16:47:53ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135129410.3390/jcm13051294Clinical Features and Outcomes of Patients with Idiopathic Inflammatory Myositis-Associated Interstitial Lung Disease in Rural Appalachia: A Cross-Sectional StudyVishal Deepak0Bhanusowmya Buragamadagu1Fnu Rida Ul Jannat2Rachel Salyer3Ty Landis4Sayanika Kaur5Bathmapriya Balakrishnan6Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USADivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USADepartment of Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USADepartment of Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USADepartment of Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USADivision of Rheumatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USARespiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USABackground: Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune disorders often complicated by interstitial lung disease (ILD). The clinical characteristics and outcomes of IIM-associated ILD have been reported variably, but the literature on rural populations is scarce. Methods: A retrospective cross-sectional study was conducted at a rural tertiary academic medical center. Twenty-nine patients met the final inclusion criteria. The primary outcome was to assess the disease state and immunological and radiographic features of IIM-associated ILD. Secondary outcomes included disease progression, ILD exacerbation, mortality rate, and factors associated with poor outcome. Results: Dermatomyositis (n = 15, 51.72%) followed by polymyositis (n = 8, 27.58%) were predominant myopathies. The most common autoantibodies were anti-Jo1 antibodies (n = 11, 37.93%). Indeterminate usual interstitial pneumonitis (41.30%, n = 12) was the most common radiographic pattern followed by non-specific interstitial pneumonia (n = 5, 17.24%). ILD exacerbation (n = 14, 66.66%) and mortality rate (n = 6, 20.69%) were high. Albumin levels were significantly lower in patients who died. Conclusions: The clinical characteristics of patients with IIM-associated ILD in rural Appalachia exhibit notable distinctions, and outcomes are worse compared to other populations. Larger studies are needed to investigate other prognostics factors and longitudinal trends of clinical characteristics and outcomes of IIM-associated ILD in rural populations.https://www.mdpi.com/2077-0383/13/5/1294idiopathic inflammatory myositisinterstitial lung diseaseruralmortalityhypoalbuminemia |
| spellingShingle | Vishal Deepak Bhanusowmya Buragamadagu Fnu Rida Ul Jannat Rachel Salyer Ty Landis Sayanika Kaur Bathmapriya Balakrishnan Clinical Features and Outcomes of Patients with Idiopathic Inflammatory Myositis-Associated Interstitial Lung Disease in Rural Appalachia: A Cross-Sectional Study Journal of Clinical Medicine idiopathic inflammatory myositis interstitial lung disease rural mortality hypoalbuminemia |
| title | Clinical Features and Outcomes of Patients with Idiopathic Inflammatory Myositis-Associated Interstitial Lung Disease in Rural Appalachia: A Cross-Sectional Study |
| title_full | Clinical Features and Outcomes of Patients with Idiopathic Inflammatory Myositis-Associated Interstitial Lung Disease in Rural Appalachia: A Cross-Sectional Study |
| title_fullStr | Clinical Features and Outcomes of Patients with Idiopathic Inflammatory Myositis-Associated Interstitial Lung Disease in Rural Appalachia: A Cross-Sectional Study |
| title_full_unstemmed | Clinical Features and Outcomes of Patients with Idiopathic Inflammatory Myositis-Associated Interstitial Lung Disease in Rural Appalachia: A Cross-Sectional Study |
| title_short | Clinical Features and Outcomes of Patients with Idiopathic Inflammatory Myositis-Associated Interstitial Lung Disease in Rural Appalachia: A Cross-Sectional Study |
| title_sort | clinical features and outcomes of patients with idiopathic inflammatory myositis associated interstitial lung disease in rural appalachia a cross sectional study |
| topic | idiopathic inflammatory myositis interstitial lung disease rural mortality hypoalbuminemia |
| url | https://www.mdpi.com/2077-0383/13/5/1294 |
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