TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITY
Plasmacytoid dendritic cells (pDCs) are a particular subset of DCs that link innate and adaptive immunity. They are responsible for the substantial production of type 1 interferon (IFN-I) in response to viral RNA or DNA through activation of TLR7 and 9. Furthermore, pDCs present antigens and induce...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00059/full |
| _version_ | 1831646733860339712 |
|---|---|
| author | Leslie eGuery Stephanie eHugues |
| author_facet | Leslie eGuery Stephanie eHugues |
| author_sort | Leslie eGuery |
| collection | DOAJ |
| description | Plasmacytoid dendritic cells (pDCs) are a particular subset of DCs that link innate and adaptive immunity. They are responsible for the substantial production of type 1 interferon (IFN-I) in response to viral RNA or DNA through activation of TLR7 and 9. Furthermore, pDCs present antigens and induce naïve T cell differentiation. It has been demonstrated that pDCs can induce immunogenic T cell responses through differentiation of cytotoxic CD8+ T cells and effector CD4+ T cells. Conversely, pDCs exhibit strong tolerogenic functions by inducing CD8+ T cell deletion, CD4+ T cell anergy, and Treg differentiation. However, since IFN-I produced by pDCs efficiently activates and recruits conventional DCs, B cells, T cells and NK cells, pDCs also indirectly affect the nature and the amplitude of adaptive immune responses. As a consequence, the precise role of antigen-presenting functions of pDCs in adaptive immunity has been difficult to dissect in vivo. Additionally, different experimental procedures led to conflicting results regarding the outcome of T cell responses induced by pDCs. During the development of autoimmunity, pDCs have been shown to play both immunogenic and tolerogenic functions depending on disease, disease progression and the experimental conditions. In this review, we will discuss the relative contribution of innate and adaptive pDC functions in modulating T cell responses, particularly during the development of autoimmunity. |
| first_indexed | 2024-12-19T14:00:06Z |
| format | Article |
| id | doaj.art-6cf5f4e4b4284a3b91b5121835b40c86 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T14:00:06Z |
| publishDate | 2013-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6cf5f4e4b4284a3b91b5121835b40c862022-12-21T20:18:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-03-01410.3389/fimmu.2013.0005943825TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITYLeslie eGuery0Stephanie eHugues1Faculty of MedicineFaculty of MedicinePlasmacytoid dendritic cells (pDCs) are a particular subset of DCs that link innate and adaptive immunity. They are responsible for the substantial production of type 1 interferon (IFN-I) in response to viral RNA or DNA through activation of TLR7 and 9. Furthermore, pDCs present antigens and induce naïve T cell differentiation. It has been demonstrated that pDCs can induce immunogenic T cell responses through differentiation of cytotoxic CD8+ T cells and effector CD4+ T cells. Conversely, pDCs exhibit strong tolerogenic functions by inducing CD8+ T cell deletion, CD4+ T cell anergy, and Treg differentiation. However, since IFN-I produced by pDCs efficiently activates and recruits conventional DCs, B cells, T cells and NK cells, pDCs also indirectly affect the nature and the amplitude of adaptive immune responses. As a consequence, the precise role of antigen-presenting functions of pDCs in adaptive immunity has been difficult to dissect in vivo. Additionally, different experimental procedures led to conflicting results regarding the outcome of T cell responses induced by pDCs. During the development of autoimmunity, pDCs have been shown to play both immunogenic and tolerogenic functions depending on disease, disease progression and the experimental conditions. In this review, we will discuss the relative contribution of innate and adaptive pDC functions in modulating T cell responses, particularly during the development of autoimmunity.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00059/fullAutoimmunitytoleranceplasmacytoid dendritic cellsantigen-presentationtype-I IFNs |
| spellingShingle | Leslie eGuery Stephanie eHugues TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITY Frontiers in Immunology Autoimmunity tolerance plasmacytoid dendritic cells antigen-presentation type-I IFNs |
| title | TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITY |
| title_full | TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITY |
| title_fullStr | TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITY |
| title_full_unstemmed | TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITY |
| title_short | TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITY |
| title_sort | tolerogenic and activatory plasmacytoid dendritic cells in autoimmunity |
| topic | Autoimmunity tolerance plasmacytoid dendritic cells antigen-presentation type-I IFNs |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00059/full |
| work_keys_str_mv | AT leslieeguery tolerogenicandactivatoryplasmacytoiddendriticcellsinautoimmunity AT stephanieehugues tolerogenicandactivatoryplasmacytoiddendriticcellsinautoimmunity |