Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases
A major global concern is the emergence and spread of systemic life –threatening fungal infections in critically ill patients. The increase in invasive fungal infections, caused most commonly by Candida and Aspergillus species, occurs in patients with impaired defenses due to a number of reasons suc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-11-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01322/full |
| _version_ | 1811283069215178752 |
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| author | Sharada eRavikumar Mar Soe eWin Louis Yi Ann Chai |
| author_facet | Sharada eRavikumar Mar Soe eWin Louis Yi Ann Chai |
| author_sort | Sharada eRavikumar |
| collection | DOAJ |
| description | A major global concern is the emergence and spread of systemic life –threatening fungal infections in critically ill patients. The increase in invasive fungal infections, caused most commonly by Candida and Aspergillus species, occurs in patients with impaired defenses due to a number of reasons such as underlying disease, the use of chemotherapeutic and immunosuppressive agents, broad-spectrum antibiotics, prosthetic devices and grafts, burns, neutropenia and HIV infection. The high morbidity and mortality associated with these infections is compounded by the limited therapeutic options and the emergence of drug resistant fungi. Hence, creative approaches to bridge the significant gap in antifungal drug development needs to be explored. Here, we review the potential anti-fungal targets for patient-centered therapies and immune-enhancing strategies for the prevention and treatment of invasive fungal diseases. |
| first_indexed | 2024-04-13T02:03:57Z |
| format | Article |
| id | doaj.art-6cf6d18938fb4b989a11ed972df93e27 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T02:03:57Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-6cf6d18938fb4b989a11ed972df93e272022-12-22T03:07:31ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-11-01610.3389/fmicb.2015.01322167202Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal DiseasesSharada eRavikumar0Mar Soe eWin1Louis Yi Ann Chai2National University Health SystemNational University Health SystemNational University Health SystemA major global concern is the emergence and spread of systemic life –threatening fungal infections in critically ill patients. The increase in invasive fungal infections, caused most commonly by Candida and Aspergillus species, occurs in patients with impaired defenses due to a number of reasons such as underlying disease, the use of chemotherapeutic and immunosuppressive agents, broad-spectrum antibiotics, prosthetic devices and grafts, burns, neutropenia and HIV infection. The high morbidity and mortality associated with these infections is compounded by the limited therapeutic options and the emergence of drug resistant fungi. Hence, creative approaches to bridge the significant gap in antifungal drug development needs to be explored. Here, we review the potential anti-fungal targets for patient-centered therapies and immune-enhancing strategies for the prevention and treatment of invasive fungal diseases.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01322/fullCytokinesImmunocompromised HostImmune RegulationInvasive fungal diseaseimmune enhancement therapy |
| spellingShingle | Sharada eRavikumar Mar Soe eWin Louis Yi Ann Chai Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases Frontiers in Microbiology Cytokines Immunocompromised Host Immune Regulation Invasive fungal disease immune enhancement therapy |
| title | Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases |
| title_full | Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases |
| title_fullStr | Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases |
| title_full_unstemmed | Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases |
| title_short | Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases |
| title_sort | optimizing outcomes in immunocompromised hosts understanding the role of immunotherapy in invasive fungal diseases |
| topic | Cytokines Immunocompromised Host Immune Regulation Invasive fungal disease immune enhancement therapy |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01322/full |
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