Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia
Nephropathia Epidemica (NE), endemic to several Volga regions of Russia, including the Republic of Tatarstan (RT) and the Republic of Mordovia (RM), is a mild form of hemorrhagic fever with renal syndrome caused by infection with rodent-borne orthohantaviruses. Although NE cases have been reported f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/5/527 |
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| author | Ekaterina Martynova Yuriy Davidyuk Emmanuel Kabwe Ekaterina E. Garanina Venera Shakirova Vera Pavelkina Yulia Uskova Robert J. Stott Toshana L. Foster Maria Markelova Mehendi Goyal Abhimat Gupta Mannan Bhola Vinay Kumar Manoj Baranwal Albert A. Rizvanov Svetlana F. Khaiboullina |
| author_facet | Ekaterina Martynova Yuriy Davidyuk Emmanuel Kabwe Ekaterina E. Garanina Venera Shakirova Vera Pavelkina Yulia Uskova Robert J. Stott Toshana L. Foster Maria Markelova Mehendi Goyal Abhimat Gupta Mannan Bhola Vinay Kumar Manoj Baranwal Albert A. Rizvanov Svetlana F. Khaiboullina |
| author_sort | Ekaterina Martynova |
| collection | DOAJ |
| description | Nephropathia Epidemica (NE), endemic to several Volga regions of Russia, including the Republic of Tatarstan (RT) and the Republic of Mordovia (RM), is a mild form of hemorrhagic fever with renal syndrome caused by infection with rodent-borne orthohantaviruses. Although NE cases have been reported for decades, little is known about the hantavirus strains associated with human infection in these regions. There is also limited understanding of the pathogenesis of NE in the RT and the RM. To address these knowledge gaps, we conducted comparative analyses of patients with NE in the RT and the RM. Clinical symptoms were more severe in patients with NE from the RM with longer observed duration of fever symptoms and hospitalization. Analysis of patient sera showed changes in the levels of numerous cytokines, chemokines, and matrix metalloproteases (MMPs) in patients with NE from both the RT and the RM, suggesting leukocyte activation, extracellular matrix degradation, and leukocyte chemotaxis. Interestingly, levels of several cytokines were distinctly different between patients NE from the RT when compared with those from the RM. These differences were not related to the genetic variation of orthohantaviruses circulating in those regions, as sequence analysis showed that Puumala virus (PUUV) was the causative agent of NE in these regions. Additionally, only the “Russia” (RUS) genetic lineage of PUUV was detected in the serum samples of patients with NE from both the RT and the RM. We therefore conclude that differences in serum cytokine, chemokine, and MMP levels between the RT and the RM are related to environmental factors and lifestyle differences that influence individual immune responses to orthohantavirus infection. |
| first_indexed | 2024-03-10T11:55:02Z |
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| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T11:55:02Z |
| publishDate | 2021-04-01 |
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| series | Pathogens |
| spelling | doaj.art-6cf72d7556564c82ba0e1bda40eca4df2023-11-21T17:21:19ZengMDPI AGPathogens2076-08172021-04-0110552710.3390/pathogens10050527Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, RussiaEkaterina Martynova0Yuriy Davidyuk1Emmanuel Kabwe2Ekaterina E. Garanina3Venera Shakirova4Vera Pavelkina5Yulia Uskova6Robert J. Stott7Toshana L. Foster8Maria Markelova9Mehendi Goyal10Abhimat Gupta11Mannan Bhola12Vinay Kumar13Manoj Baranwal14Albert A. Rizvanov15Svetlana F. Khaiboullina16Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInfectious Diseases Department, Kazan State Medical Academy, 420012 Kazan, RussiaInfectious Diseases Department, National Research Ogarev Mordovia State University, 430005 Saransk, RussiaInfectious Diseases Department, National Research Ogarev Mordovia State University, 430005 Saransk, RussiaFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, Sutton Bonington Campus, The University of Nottingham, Loughborough LE12 5RD, UKFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, Sutton Bonington Campus, The University of Nottingham, Loughborough LE12 5RD, UKInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaDoconvid.ai, Bestech Business Tower, Mohali 160055, IndiaDepartment of Computer Science and Engineering, Thapar Institute of Engineering and Technology, Patiala 147004, IndiaDepartment of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, IndiaDepartment of Electronics and Communication Engineering, Thapar Institute of Engineering and Technology, Patiala 147004, IndiaDepartment of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, IndiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaNephropathia Epidemica (NE), endemic to several Volga regions of Russia, including the Republic of Tatarstan (RT) and the Republic of Mordovia (RM), is a mild form of hemorrhagic fever with renal syndrome caused by infection with rodent-borne orthohantaviruses. Although NE cases have been reported for decades, little is known about the hantavirus strains associated with human infection in these regions. There is also limited understanding of the pathogenesis of NE in the RT and the RM. To address these knowledge gaps, we conducted comparative analyses of patients with NE in the RT and the RM. Clinical symptoms were more severe in patients with NE from the RM with longer observed duration of fever symptoms and hospitalization. Analysis of patient sera showed changes in the levels of numerous cytokines, chemokines, and matrix metalloproteases (MMPs) in patients with NE from both the RT and the RM, suggesting leukocyte activation, extracellular matrix degradation, and leukocyte chemotaxis. Interestingly, levels of several cytokines were distinctly different between patients NE from the RT when compared with those from the RM. These differences were not related to the genetic variation of orthohantaviruses circulating in those regions, as sequence analysis showed that Puumala virus (PUUV) was the causative agent of NE in these regions. Additionally, only the “Russia” (RUS) genetic lineage of PUUV was detected in the serum samples of patients with NE from both the RT and the RM. We therefore conclude that differences in serum cytokine, chemokine, and MMP levels between the RT and the RM are related to environmental factors and lifestyle differences that influence individual immune responses to orthohantavirus infection.https://www.mdpi.com/2076-0817/10/5/527Nephropathia Epidemicacytokinechemokinemetalloprotease |
| spellingShingle | Ekaterina Martynova Yuriy Davidyuk Emmanuel Kabwe Ekaterina E. Garanina Venera Shakirova Vera Pavelkina Yulia Uskova Robert J. Stott Toshana L. Foster Maria Markelova Mehendi Goyal Abhimat Gupta Mannan Bhola Vinay Kumar Manoj Baranwal Albert A. Rizvanov Svetlana F. Khaiboullina Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia Pathogens Nephropathia Epidemica cytokine chemokine metalloprotease |
| title | Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia |
| title_full | Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia |
| title_fullStr | Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia |
| title_full_unstemmed | Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia |
| title_short | Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia |
| title_sort | cytokine chemokine and metalloprotease activation in the serum of patients with nephropathia epidemica from the republic of tatarstan and the republic of mordovia russia |
| topic | Nephropathia Epidemica cytokine chemokine metalloprotease |
| url | https://www.mdpi.com/2076-0817/10/5/527 |
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