In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand

In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand

The cardinal role of microtubules in cell mitosis makes them interesting drug targets for many pharmacological treatments, including those against cancer. Moreover, different expression patterns between cell types for several tubulin isotypes represent a great opportunity to improve the selectivity...

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Bibliographic Details
Main Authors: Lorenzo Pallante, Antonio Rocca, Greta Klejborowska, Adam Huczynski, Gianvito Grasso, Jack A. Tuszynski, Marco A. Deriu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Chemistry
Subjects:
molecular modeling
drug discovery
microtubule
cancer
drug resistance
tubulin
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00108/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00108/full

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