Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor
Background: The prostate-specific antigen (PSA) is an important cancer biomarker that is commonly utilized in the diagnosis of prostate cancer. The development of a PSA determination technique that is rapid, simple, and inexpensive, in addition to highly accurate, sensitive, and selective, remains a...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/11/931 |
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| author | Said M. El-Sheikh Sheta M. Sheta Salem R. Salem Mohkles M. Abd-Elzaher Amal S. Basaleh Ammar A. Labib |
| author_facet | Said M. El-Sheikh Sheta M. Sheta Salem R. Salem Mohkles M. Abd-Elzaher Amal S. Basaleh Ammar A. Labib |
| author_sort | Said M. El-Sheikh |
| collection | DOAJ |
| description | Background: The prostate-specific antigen (PSA) is an important cancer biomarker that is commonly utilized in the diagnosis of prostate cancer. The development of a PSA determination technique that is rapid, simple, and inexpensive, in addition to highly accurate, sensitive, and selective, remains a formidable obstacle. Methods: In this study, we developed a practical biosensor based on Zn(II) metal–organic framework nanoparticles (Zn-MOFs-NPs). Many spectroscopic and microanalytical tools are used to determine the structure, morphology, and physicochemical properties of the prepared MOF. Results: According to the results, Zn-MOFs-NPs are sensitive to PSA, selective to an extremely greater extent, and stable in terms of chemical composition. Furthermore, the Zn-MOFs-NPs did not exhibit any interferences from other common analytes that might cause interference. The detection limit for PSA was calculated and was 0.145 fg/mL throughout a wide linear concentration range (0.1 fg/mL–20 pg/mL). Conclusions: Zn-MOFs-NPs were successfully used as a growing biosensor for the monitoring and measurement of PSA in biological real samples. |
| first_indexed | 2024-03-09T19:14:10Z |
| format | Article |
| id | doaj.art-6cfba9cd876d408a8e77e01953256406 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T19:14:10Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-6cfba9cd876d408a8e77e019532564062023-11-24T03:54:35ZengMDPI AGBiosensors2079-63742022-10-01121193110.3390/bios12110931Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical BiosensorSaid M. El-Sheikh0Sheta M. Sheta1Salem R. Salem2Mohkles M. Abd-Elzaher3Amal S. Basaleh4Ammar A. Labib5Department of Nanomaterials and Nanotechnology, Central Metallurgical R & D Institute, Cairo 11421, EgyptDepartment of Inorganic Chemistry, National Research Centre, Cairo 12622, EgyptDepartment of Biochemistry, Egypt Centre for Research and Regenerative Medicine, Cairo 11887, EgyptDepartment of Inorganic Chemistry, National Research Centre, Cairo 12622, EgyptDepartment of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Inorganic Chemistry, National Research Centre, Cairo 12622, EgyptBackground: The prostate-specific antigen (PSA) is an important cancer biomarker that is commonly utilized in the diagnosis of prostate cancer. The development of a PSA determination technique that is rapid, simple, and inexpensive, in addition to highly accurate, sensitive, and selective, remains a formidable obstacle. Methods: In this study, we developed a practical biosensor based on Zn(II) metal–organic framework nanoparticles (Zn-MOFs-NPs). Many spectroscopic and microanalytical tools are used to determine the structure, morphology, and physicochemical properties of the prepared MOF. Results: According to the results, Zn-MOFs-NPs are sensitive to PSA, selective to an extremely greater extent, and stable in terms of chemical composition. Furthermore, the Zn-MOFs-NPs did not exhibit any interferences from other common analytes that might cause interference. The detection limit for PSA was calculated and was 0.145 fg/mL throughout a wide linear concentration range (0.1 fg/mL–20 pg/mL). Conclusions: Zn-MOFs-NPs were successfully used as a growing biosensor for the monitoring and measurement of PSA in biological real samples.https://www.mdpi.com/2079-6374/12/11/931prostate antigenphotoluminescencenanoparticlesmetal–organic framework based on zinc(ii)biosensor |
| spellingShingle | Said M. El-Sheikh Sheta M. Sheta Salem R. Salem Mohkles M. Abd-Elzaher Amal S. Basaleh Ammar A. Labib Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor Biosensors prostate antigen photoluminescence nanoparticles metal–organic framework based on zinc(ii) biosensor |
| title | Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor |
| title_full | Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor |
| title_fullStr | Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor |
| title_full_unstemmed | Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor |
| title_short | Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor |
| title_sort | prostate specific antigen monitoring using nano zinc ii metal organic framework based optical biosensor |
| topic | prostate antigen photoluminescence nanoparticles metal–organic framework based on zinc(ii) biosensor |
| url | https://www.mdpi.com/2079-6374/12/11/931 |
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