Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat
The present investigation was undertaken to evaluate immunomodulatory potential of Ajuga macrosperma against cyclophoshphamide (CP) induced immunosupression in rats. The immunological parameters such as haemaglutation (HA) titre and serum immunoglobulin (Ig) for humoral immunity (HI); lymphocyte sti...
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| Format: | Article |
| Language: | English |
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Indian Council of Agricultural Research
2021-07-01
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| Series: | Indian Journal of Animal Sciences |
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| Online Access: | https://epubs.icar.org.in/index.php/IJAnS/article/view/113168 |
| _version_ | 1797896949080260608 |
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| author | ISFAQ BASIR LONE SATYA PAL SINGH GOVIND KUMAR CHOUDHARY |
| author_facet | ISFAQ BASIR LONE SATYA PAL SINGH GOVIND KUMAR CHOUDHARY |
| author_sort | ISFAQ BASIR LONE |
| collection | DOAJ |
| description | The present investigation was undertaken to evaluate immunomodulatory potential of Ajuga macrosperma against cyclophoshphamide (CP) induced immunosupression in rats. The immunological parameters such as haemaglutation (HA) titre and serum immunoglobulin (Ig) for humoral immunity (HI); lymphocyte stimulation test (LST), phagocytic index test, neutrophil adhesion test (NAT) and delayed type hypersensitivity reaction (DTH) for cellular immunity(CMI) were determined. The cyclophoshphamide treatment significantly suppressed both HI and CMI responses, which were significantly improved following treatment with 100 ppm and 200 ppm of methanolic extract of Ajuga macrosperma (MEAM) in dose dependent manner. The decreases in HI and CMI related parameters by CP treatment revealed immunosuppresion, whereas simultaneous treatment with MEAM ameliorated immune response which indicated immunomodulatory properties of Ajuga macrosperma. |
| first_indexed | 2024-04-10T07:50:57Z |
| format | Article |
| id | doaj.art-6cfce6faacc14df0b084c1bd9263f4e3 |
| institution | Directory Open Access Journal |
| issn | 0367-8318 2394-3327 |
| language | English |
| last_indexed | 2024-04-10T07:50:57Z |
| publishDate | 2021-07-01 |
| publisher | Indian Council of Agricultural Research |
| record_format | Article |
| series | Indian Journal of Animal Sciences |
| spelling | doaj.art-6cfce6faacc14df0b084c1bd9263f4e32023-02-23T10:16:37ZengIndian Council of Agricultural ResearchIndian Journal of Animal Sciences0367-83182394-33272021-07-01901210.56093/ijans.v90i12.113168Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised ratISFAQ BASIR LONE0SATYA PAL SINGH1GOVIND KUMAR CHOUDHARY2College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, UttarakhandICAR-Krishi Vigyan Kendra, Bhadohi, Uttar PradeshGovind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakahnd 263 145 IndiaThe present investigation was undertaken to evaluate immunomodulatory potential of Ajuga macrosperma against cyclophoshphamide (CP) induced immunosupression in rats. The immunological parameters such as haemaglutation (HA) titre and serum immunoglobulin (Ig) for humoral immunity (HI); lymphocyte stimulation test (LST), phagocytic index test, neutrophil adhesion test (NAT) and delayed type hypersensitivity reaction (DTH) for cellular immunity(CMI) were determined. The cyclophoshphamide treatment significantly suppressed both HI and CMI responses, which were significantly improved following treatment with 100 ppm and 200 ppm of methanolic extract of Ajuga macrosperma (MEAM) in dose dependent manner. The decreases in HI and CMI related parameters by CP treatment revealed immunosuppresion, whereas simultaneous treatment with MEAM ameliorated immune response which indicated immunomodulatory properties of Ajuga macrosperma.https://epubs.icar.org.in/index.php/IJAnS/article/view/113168Ajuga macrospermaCyclophosphamideImmunomodulationRat |
| spellingShingle | ISFAQ BASIR LONE SATYA PAL SINGH GOVIND KUMAR CHOUDHARY Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat Indian Journal of Animal Sciences Ajuga macrosperma Cyclophosphamide Immunomodulation Rat |
| title | Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat |
| title_full | Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat |
| title_fullStr | Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat |
| title_full_unstemmed | Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat |
| title_short | Immunomodulatory efficacy of methanolic extract of Ajuga macrosperma in cyclophosphamide induced immunocompromised rat |
| title_sort | immunomodulatory efficacy of methanolic extract of ajuga macrosperma in cyclophosphamide induced immunocompromised rat |
| topic | Ajuga macrosperma Cyclophosphamide Immunomodulation Rat |
| url | https://epubs.icar.org.in/index.php/IJAnS/article/view/113168 |
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