Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study
Neurogenic dysphagia frequently occurs after stroke and deglutitive aspiration is one of the main reasons for subacute death after stroke. Although promising therapeutic interventions for neurogenic dysphagia are being developed, the functional neuroanatomy of recovered swallowing in this population...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315821630081X |
| _version_ | 1819183179071750144 |
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| author | Paul Glad Mihai Mareile Otto Martin Domin Thomas Platz Shaheen Hamdy Martin Lotze |
| author_facet | Paul Glad Mihai Mareile Otto Martin Domin Thomas Platz Shaheen Hamdy Martin Lotze |
| author_sort | Paul Glad Mihai |
| collection | DOAJ |
| description | Neurogenic dysphagia frequently occurs after stroke and deglutitive aspiration is one of the main reasons for subacute death after stroke. Although promising therapeutic interventions for neurogenic dysphagia are being developed, the functional neuroanatomy of recovered swallowing in this population remains uncertain. Here, we investigated 18 patients post-stroke who recovered from dysphagia using an event related functional magnetic resonance imaging (fMRI) study of swallowing. Patients were characterized by initial dysphagia score (mild to severe), lesion mapping, white matter fractional anisotropy (FA) of the pyramidal tracts, and swallowing performance measurement during fMRI scanning. Eighteen age matched healthy participants served as a control group. Overall, patients showed decreased fMRI-activation in the entire swallowing network apart from an increase of activation in the contralesional primary somatosensory cortex (S1). Moreover, fMRI activation in contralesional S1 correlated with initial dysphagia score. Finally, when lesions of the pyramidal tract were more severe, recovered swallowing appeared to be associated with asymmetric activation of the ipsilesional anterior cerebellum. Taken together, our data support a role for increased contralesional somatosensory resources and ipsilesional anterior cerebellum feed forward loops for recovered swallowing after dysphagia following stroke. |
| first_indexed | 2024-12-22T22:57:54Z |
| format | Article |
| id | doaj.art-6cfcf04010094120bcf24d3e897d7cbc |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-22T22:57:54Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-6cfcf04010094120bcf24d3e897d7cbc2022-12-21T18:09:46ZengElsevierNeuroImage: Clinical2213-15822016-01-0112C1013102110.1016/j.nicl.2016.05.006Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI studyPaul Glad Mihai0Mareile Otto1Martin Domin2Thomas Platz3Shaheen Hamdy4Martin Lotze5Functional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, University Medicine, University of Greifswald, GermanyBDH-Klinik Greifswald, Neurorehabilitation Centre and Spinal Cord Injury Unit, University of Greifswald, GermanyFunctional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, University Medicine, University of Greifswald, GermanyBDH-Klinik Greifswald, Neurorehabilitation Centre and Spinal Cord Injury Unit, University of Greifswald, GermanyCentre for Gastrointestinal Sciences, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, UKFunctional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, University Medicine, University of Greifswald, GermanyNeurogenic dysphagia frequently occurs after stroke and deglutitive aspiration is one of the main reasons for subacute death after stroke. Although promising therapeutic interventions for neurogenic dysphagia are being developed, the functional neuroanatomy of recovered swallowing in this population remains uncertain. Here, we investigated 18 patients post-stroke who recovered from dysphagia using an event related functional magnetic resonance imaging (fMRI) study of swallowing. Patients were characterized by initial dysphagia score (mild to severe), lesion mapping, white matter fractional anisotropy (FA) of the pyramidal tracts, and swallowing performance measurement during fMRI scanning. Eighteen age matched healthy participants served as a control group. Overall, patients showed decreased fMRI-activation in the entire swallowing network apart from an increase of activation in the contralesional primary somatosensory cortex (S1). Moreover, fMRI activation in contralesional S1 correlated with initial dysphagia score. Finally, when lesions of the pyramidal tract were more severe, recovered swallowing appeared to be associated with asymmetric activation of the ipsilesional anterior cerebellum. Taken together, our data support a role for increased contralesional somatosensory resources and ipsilesional anterior cerebellum feed forward loops for recovered swallowing after dysphagia following stroke.http://www.sciencedirect.com/science/article/pii/S221315821630081XDysphagiaNeurorehabilitationRecoveryStrokeSwallowing |
| spellingShingle | Paul Glad Mihai Mareile Otto Martin Domin Thomas Platz Shaheen Hamdy Martin Lotze Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study NeuroImage: Clinical Dysphagia Neurorehabilitation Recovery Stroke Swallowing |
| title | Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study |
| title_full | Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study |
| title_fullStr | Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study |
| title_full_unstemmed | Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study |
| title_short | Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study |
| title_sort | brain imaging correlates of recovered swallowing after dysphagic stroke a fmri and dwi study |
| topic | Dysphagia Neurorehabilitation Recovery Stroke Swallowing |
| url | http://www.sciencedirect.com/science/article/pii/S221315821630081X |
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