Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac Disease
Increased gut permeability has been suggested in patients with celiac disease (CD). We aimed to compare gut permeability in children using the lactulose/rhamnose permeability test. We prospectively recruited 55 children into 3 groups; 27 in group 1 (children with newly diagnosed celiac disease, 12 i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-11-01
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| Series: | Global Pediatric Health |
| Online Access: | https://doi.org/10.1177/2333794X20969278 |
| _version_ | 1818266559110447104 |
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| author | Muhammad Rehan Khan MD William A. Faubion MD Roy Dyer PhD Ravinder Singh PhD Joseph J. Larson MS Imad Absah MD |
| author_facet | Muhammad Rehan Khan MD William A. Faubion MD Roy Dyer PhD Ravinder Singh PhD Joseph J. Larson MS Imad Absah MD |
| author_sort | Muhammad Rehan Khan MD |
| collection | DOAJ |
| description | Increased gut permeability has been suggested in patients with celiac disease (CD). We aimed to compare gut permeability in children using the lactulose/rhamnose permeability test. We prospectively recruited 55 children into 3 groups; 27 in group 1 (children with newly diagnosed celiac disease, 12 in group 2 (siblings of children with celiac disease) and 16 in group 3 (control group). The median age of participants was 11 years 2 months in group 1, 9 years 5 months in group 2 and 10 years 3 months in group 3. Standardized median delta rhamnose was lower in CD group as compared to control group (147.5 vs 3153.1, P = 0.040). The low median rhamnose absorption in children with celiac disease as compared to other groups suggests that this test can differentiate between damaged and healthy mucosa, hence can it potentially can be used as a noninvasive test of mucosal healing in children with celiac disease. |
| first_indexed | 2024-12-12T20:08:37Z |
| format | Article |
| id | doaj.art-6cfd1fe530074776981fe41d8d60861f |
| institution | Directory Open Access Journal |
| issn | 2333-794X |
| language | English |
| last_indexed | 2024-12-12T20:08:37Z |
| publishDate | 2020-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Global Pediatric Health |
| spelling | doaj.art-6cfd1fe530074776981fe41d8d60861f2022-12-22T00:13:35ZengSAGE PublishingGlobal Pediatric Health2333-794X2020-11-01710.1177/2333794X20969278Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac DiseaseMuhammad Rehan Khan MD0William A. Faubion MD1Roy Dyer PhD2Ravinder Singh PhD3Joseph J. Larson MS4Imad Absah MD5University of Illinois College of Medicine at Peoria; Children’s Hospital of Illinois, Peroia, Illinois, USAMayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAMayo Clinic, Rochester, MN, USAIncreased gut permeability has been suggested in patients with celiac disease (CD). We aimed to compare gut permeability in children using the lactulose/rhamnose permeability test. We prospectively recruited 55 children into 3 groups; 27 in group 1 (children with newly diagnosed celiac disease, 12 in group 2 (siblings of children with celiac disease) and 16 in group 3 (control group). The median age of participants was 11 years 2 months in group 1, 9 years 5 months in group 2 and 10 years 3 months in group 3. Standardized median delta rhamnose was lower in CD group as compared to control group (147.5 vs 3153.1, P = 0.040). The low median rhamnose absorption in children with celiac disease as compared to other groups suggests that this test can differentiate between damaged and healthy mucosa, hence can it potentially can be used as a noninvasive test of mucosal healing in children with celiac disease.https://doi.org/10.1177/2333794X20969278 |
| spellingShingle | Muhammad Rehan Khan MD William A. Faubion MD Roy Dyer PhD Ravinder Singh PhD Joseph J. Larson MS Imad Absah MD Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac Disease Global Pediatric Health |
| title | Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac Disease |
| title_full | Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac Disease |
| title_fullStr | Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac Disease |
| title_full_unstemmed | Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac Disease |
| title_short | Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac Disease |
| title_sort | role of lactulose rhamnose permeability test in assessing small bowel mucosal damage in children with celiac disease |
| url | https://doi.org/10.1177/2333794X20969278 |
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