An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community
Severe pneumonia due to Candida tropicalis infection mainly occurs in immunosuppressed patients or those currently receiving broad-spectrum antibiotics. Herein, we report a case of severe pneumonia caused due to C tropicalis in an elderly patient. A 72-year-old man with a previous history of hyperte...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-02-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096231154652 |
| _version_ | 1811169163403591680 |
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| author | Killen H. Briones-Claudett MD, MSc H. Mónica Briones-Claudett MSc, MD Roger Alexander Murillo Vasconez MD Cynthia K. Bajaña Huilcapi MD Carolina del Rosario Rivera Salas MD Jaime Benitez Sólis MD, MSc Domenica F. Estupinan Vargas MD Henry Parra-Vera MSc Killen H. Briones Zamora MS Diana C. Briones Marquez MD Michelle Grunauer MD, PhD |
| author_facet | Killen H. Briones-Claudett MD, MSc H. Mónica Briones-Claudett MSc, MD Roger Alexander Murillo Vasconez MD Cynthia K. Bajaña Huilcapi MD Carolina del Rosario Rivera Salas MD Jaime Benitez Sólis MD, MSc Domenica F. Estupinan Vargas MD Henry Parra-Vera MSc Killen H. Briones Zamora MS Diana C. Briones Marquez MD Michelle Grunauer MD, PhD |
| author_sort | Killen H. Briones-Claudett MD, MSc |
| collection | DOAJ |
| description | Severe pneumonia due to Candida tropicalis infection mainly occurs in immunosuppressed patients or those currently receiving broad-spectrum antibiotics. Herein, we report a case of severe pneumonia caused due to C tropicalis in an elderly patient. A 72-year-old man with a previous history of hypertension, ischemic stroke, and facial paralysis sequelae treated with the botulinic toxin, was admitted to the hospital for dyspnea. Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection was negative. Computed tomography of the chest revealed bilateral consolidation with left predominance. A bronchoalveolar lavage sample was sent to molecular biology, but no microorganisms were detected using a FilmArray respiratory panel. However, mamanocandidas test for candida was 166 pg/mL (positive), and fungal structures were identified by the MALDI-TOF Biotyper mass spectrometry and attributed to C tropicalis . Antifungal therapy was started using caspofungin 75 mg as the initial dose followed by 50 mg daily. After 10 days of treatment, ventilatory weaning was achieved. By day 14, the patient was decannulated from the tracheostomy. Oral antifungal treatment with voriconazole was continued, and he was discharged from intensive care in good clinical condition. Severe pneumonia due to C tropicalis might occur in specific cases, especially in those patients with risk factors, and must thus be considered when approaching such cases. |
| first_indexed | 2024-04-10T16:38:55Z |
| format | Article |
| id | doaj.art-6cfe999a4ac94559a1baf13543f9278d |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-04-10T16:38:55Z |
| publishDate | 2023-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-6cfe999a4ac94559a1baf13543f9278d2023-02-08T10:33:23ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962023-02-011110.1177/23247096231154652An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the CommunityKillen H. Briones-Claudett MD, MSc0H. Mónica Briones-Claudett MSc, MD1Roger Alexander Murillo Vasconez MD2Cynthia K. Bajaña Huilcapi MD3Carolina del Rosario Rivera Salas MD4Jaime Benitez Sólis MD, MSc5Domenica F. Estupinan Vargas MD6Henry Parra-Vera MSc7Killen H. Briones Zamora MS8Diana C. Briones Marquez MD9Michelle Grunauer MD, PhD10Ecuadorian Institute of Social Security, Babahoyo, EcuadorEcuadorian Institute of Social Security, Babahoyo, EcuadorEcuadorian Institute of Social Security, Babahoyo, EcuadorEcuadorian Institute of Social Security, Babahoyo, EcuadorEcuadorian Institute of Social Security, Babahoyo, EcuadorOMNI Hospital, Guayaquil, EcuadorPhysiology and Respiratory-Center Briones-Claudett, EcuadorCentro de Investigación Microbiológica, Guayaquil, EcuadorUniversidad Espíritu Santo, Samborondón, EcuadorUniversidad de Guayaquil, EcuadorUniversidad San Francisco de Quito, EcuadorSevere pneumonia due to Candida tropicalis infection mainly occurs in immunosuppressed patients or those currently receiving broad-spectrum antibiotics. Herein, we report a case of severe pneumonia caused due to C tropicalis in an elderly patient. A 72-year-old man with a previous history of hypertension, ischemic stroke, and facial paralysis sequelae treated with the botulinic toxin, was admitted to the hospital for dyspnea. Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection was negative. Computed tomography of the chest revealed bilateral consolidation with left predominance. A bronchoalveolar lavage sample was sent to molecular biology, but no microorganisms were detected using a FilmArray respiratory panel. However, mamanocandidas test for candida was 166 pg/mL (positive), and fungal structures were identified by the MALDI-TOF Biotyper mass spectrometry and attributed to C tropicalis . Antifungal therapy was started using caspofungin 75 mg as the initial dose followed by 50 mg daily. After 10 days of treatment, ventilatory weaning was achieved. By day 14, the patient was decannulated from the tracheostomy. Oral antifungal treatment with voriconazole was continued, and he was discharged from intensive care in good clinical condition. Severe pneumonia due to C tropicalis might occur in specific cases, especially in those patients with risk factors, and must thus be considered when approaching such cases.https://doi.org/10.1177/23247096231154652 |
| spellingShingle | Killen H. Briones-Claudett MD, MSc H. Mónica Briones-Claudett MSc, MD Roger Alexander Murillo Vasconez MD Cynthia K. Bajaña Huilcapi MD Carolina del Rosario Rivera Salas MD Jaime Benitez Sólis MD, MSc Domenica F. Estupinan Vargas MD Henry Parra-Vera MSc Killen H. Briones Zamora MS Diana C. Briones Marquez MD Michelle Grunauer MD, PhD An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community Journal of Investigative Medicine High Impact Case Reports |
| title | An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community |
| title_full | An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community |
| title_fullStr | An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community |
| title_full_unstemmed | An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community |
| title_short | An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community |
| title_sort | unusual case of severe pneumonia caused due with a favorable clinical response to antifungals in a nonimmunocompromised patient from the community |
| url | https://doi.org/10.1177/23247096231154652 |
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