Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion
Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists. In this st...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/20/15382 |
| _version_ | 1797573627414052864 |
|---|---|
| author | Elisa Franzi Gregory Mathez Soraya Dinant Charlotte Deloizy Laurent Kaiser Caroline Tapparel Ronan Le Goffic Valeria Cagno |
| author_facet | Elisa Franzi Gregory Mathez Soraya Dinant Charlotte Deloizy Laurent Kaiser Caroline Tapparel Ronan Le Goffic Valeria Cagno |
| author_sort | Elisa Franzi |
| collection | DOAJ |
| description | Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists. In this study, we identified non-steroidal estrogens as potent inhibitors of influenza virus due to their interaction with the hemagglutinin protein, preventing viral entry. This activity is maintained in vitro, ex vivo, and in vivo. Therefore, we found a new domain to target on the hemagglutinin and a class of compounds that could be further optimized for influenza treatment. |
| first_indexed | 2024-03-10T21:11:47Z |
| format | Article |
| id | doaj.art-6cfef9607bd846cbb8ee20a7828a9a9a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:11:47Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6cfef9607bd846cbb8ee20a7828a9a9a2023-11-19T16:45:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124201538210.3390/ijms242015382Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral FusionElisa Franzi0Gregory Mathez1Soraya Dinant2Charlotte Deloizy3Laurent Kaiser4Caroline Tapparel5Ronan Le Goffic6Valeria Cagno7Institute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandInstitute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandINRAE, UVSQ, UMR892 VIM, Université Paris-Saclay, 78350 Jouy-en-Josas, FranceINRAE, UVSQ, UMR892 VIM, Université Paris-Saclay, 78350 Jouy-en-Josas, FranceLaboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, University of Geneva, 1206 Geneva, SwitzerlandDepartment of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, SwitzerlandINRAE, UVSQ, UMR892 VIM, Université Paris-Saclay, 78350 Jouy-en-Josas, FranceInstitute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandInfluenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists. In this study, we identified non-steroidal estrogens as potent inhibitors of influenza virus due to their interaction with the hemagglutinin protein, preventing viral entry. This activity is maintained in vitro, ex vivo, and in vivo. Therefore, we found a new domain to target on the hemagglutinin and a class of compounds that could be further optimized for influenza treatment.https://www.mdpi.com/1422-0067/24/20/15382influenza virushemagglutininentryscreeningantiviralestrogens |
| spellingShingle | Elisa Franzi Gregory Mathez Soraya Dinant Charlotte Deloizy Laurent Kaiser Caroline Tapparel Ronan Le Goffic Valeria Cagno Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion International Journal of Molecular Sciences influenza virus hemagglutinin entry screening antiviral estrogens |
| title | Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion |
| title_full | Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion |
| title_fullStr | Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion |
| title_full_unstemmed | Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion |
| title_short | Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion |
| title_sort | non steroidal estrogens inhibit influenza virus by interacting with hemagglutinin and preventing viral fusion |
| topic | influenza virus hemagglutinin entry screening antiviral estrogens |
| url | https://www.mdpi.com/1422-0067/24/20/15382 |
| work_keys_str_mv | AT elisafranzi nonsteroidalestrogensinhibitinfluenzavirusbyinteractingwithhemagglutininandpreventingviralfusion AT gregorymathez nonsteroidalestrogensinhibitinfluenzavirusbyinteractingwithhemagglutininandpreventingviralfusion AT sorayadinant nonsteroidalestrogensinhibitinfluenzavirusbyinteractingwithhemagglutininandpreventingviralfusion AT charlottedeloizy nonsteroidalestrogensinhibitinfluenzavirusbyinteractingwithhemagglutininandpreventingviralfusion AT laurentkaiser nonsteroidalestrogensinhibitinfluenzavirusbyinteractingwithhemagglutininandpreventingviralfusion AT carolinetapparel nonsteroidalestrogensinhibitinfluenzavirusbyinteractingwithhemagglutininandpreventingviralfusion AT ronanlegoffic nonsteroidalestrogensinhibitinfluenzavirusbyinteractingwithhemagglutininandpreventingviralfusion AT valeriacagno nonsteroidalestrogensinhibitinfluenzavirusbyinteractingwithhemagglutininandpreventingviralfusion |