Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach
Capsaicin is known to activate heat receptor TRPV1 and induce changes in thermoregulatory processes of mammals. However, the mechanism by which capsaicin induces thermoregulatory responses in invertebrates is unknown. Insect thermoreceptors belong to the TRP receptors family, and are known to be act...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/23/12/3360 |
| _version_ | 1819013375253807104 |
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| author | Justyna Maliszewska Milena Jankowska Hanna Kletkiewicz Maria Stankiewicz Justyna Rogalska |
| author_facet | Justyna Maliszewska Milena Jankowska Hanna Kletkiewicz Maria Stankiewicz Justyna Rogalska |
| author_sort | Justyna Maliszewska |
| collection | DOAJ |
| description | Capsaicin is known to activate heat receptor TRPV1 and induce changes in thermoregulatory processes of mammals. However, the mechanism by which capsaicin induces thermoregulatory responses in invertebrates is unknown. Insect thermoreceptors belong to the TRP receptors family, and are known to be activated not only by temperature, but also by other stimuli. In the following study, we evaluated the effects of different ligands that have been shown to activate (allyl isothiocyanate) or inhibit (camphor) heat receptors, as well as, activate (camphor) or inhibit (menthol and thymol) cold receptors in insects. Moreover, we decided to determine the effect of agonist (capsaicin) and antagonist (capsazepine) of mammalian heat receptor on the American cockroach’s thermoregulatory processes. We observed that capsaicin induced the decrease of the head temperature of immobilized cockroaches. Moreover, the examined ligands induced preference for colder environments, when insects were allowed to choose the ambient temperature. Camphor exposure resulted in a preference for warm environments, but the changes in body temperature were not observed. The results suggest that capsaicin acts on the heat receptor in cockroaches and that TRP receptors are involved in cockroaches’ thermosensation. |
| first_indexed | 2024-12-21T01:58:57Z |
| format | Article |
| id | doaj.art-6d018b5070654c92a38c56f3750e7550 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T01:58:57Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6d018b5070654c92a38c56f3750e75502022-12-21T19:19:40ZengMDPI AGMolecules1420-30492018-12-012312336010.3390/molecules23123360molecules23123360Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American CockroachJustyna Maliszewska0Milena Jankowska1Hanna Kletkiewicz2Maria Stankiewicz3Justyna Rogalska4Department of Animal Physiology, Faculty of Biology and Environmental Protection, Nicolaus Copernicus University, 87-100 Toruń, PolandDepartment of Biophysics, Faculty of Biology and Environmental Protection, Nicolaus Copernicus University, 87-100 Toruń, PolandDepartment of Animal Physiology, Faculty of Biology and Environmental Protection, Nicolaus Copernicus University, 87-100 Toruń, PolandDepartment of Biophysics, Faculty of Biology and Environmental Protection, Nicolaus Copernicus University, 87-100 Toruń, PolandDepartment of Animal Physiology, Faculty of Biology and Environmental Protection, Nicolaus Copernicus University, 87-100 Toruń, PolandCapsaicin is known to activate heat receptor TRPV1 and induce changes in thermoregulatory processes of mammals. However, the mechanism by which capsaicin induces thermoregulatory responses in invertebrates is unknown. Insect thermoreceptors belong to the TRP receptors family, and are known to be activated not only by temperature, but also by other stimuli. In the following study, we evaluated the effects of different ligands that have been shown to activate (allyl isothiocyanate) or inhibit (camphor) heat receptors, as well as, activate (camphor) or inhibit (menthol and thymol) cold receptors in insects. Moreover, we decided to determine the effect of agonist (capsaicin) and antagonist (capsazepine) of mammalian heat receptor on the American cockroach’s thermoregulatory processes. We observed that capsaicin induced the decrease of the head temperature of immobilized cockroaches. Moreover, the examined ligands induced preference for colder environments, when insects were allowed to choose the ambient temperature. Camphor exposure resulted in a preference for warm environments, but the changes in body temperature were not observed. The results suggest that capsaicin acts on the heat receptor in cockroaches and that TRP receptors are involved in cockroaches’ thermosensation.https://www.mdpi.com/1420-3049/23/12/3360temperature perceptionTRP receptorsbehavioral thermoregulationAmerican cockroachallyl isothiocyanatecapsaicincamphormentholthymol |
| spellingShingle | Justyna Maliszewska Milena Jankowska Hanna Kletkiewicz Maria Stankiewicz Justyna Rogalska Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach Molecules temperature perception TRP receptors behavioral thermoregulation American cockroach allyl isothiocyanate capsaicin camphor menthol thymol |
| title | Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach |
| title_full | Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach |
| title_fullStr | Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach |
| title_full_unstemmed | Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach |
| title_short | Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach |
| title_sort | effect of capsaicin and other thermo trp agonists on thermoregulatory processes in the american cockroach |
| topic | temperature perception TRP receptors behavioral thermoregulation American cockroach allyl isothiocyanate capsaicin camphor menthol thymol |
| url | https://www.mdpi.com/1420-3049/23/12/3360 |
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